[OT...] Posted September 12, 2012 Share Posted September 12, 2012 There is some good scientific evidence that naltrexone can be used to cure someone of alcoholism or opioid addiction. http://en.wikipedia.org/wiki/Naltrexone (For tablet form, a patient following the Sinclair Method takes a 50 mg tablet one hour before every drinking session. Patients who achieve success with the treatment experience a reduced urge to drink over time.) But for our purposes, there is emerging evidence via clinical trials that Naltrexone can be used to treat other afflictions: Depersonalization disorder Naltrexone is sometimes used in the treatment of depersonalization disorder. While studies have suggested it is less effective than naloxone for treating depersonalization, naloxone is impractical for daily use because it must be injected intravenously. A 2005 naltrexone study demonstrated an average of 30% reduction of depersonalization symptoms, as measured by 3 validated dissociation scales. Most of the efforts in studying naltrexone for depersonalization thus far have been directed by Dr. Daphne Simeon at the Mount Sinai School of Medicine. Id. And even sex addiction. http://www.mayoclinicproceedings.org/article/S0025-6196(11)60846-X/fulltext The most interesting is an Australian study which seems to give hope that Naltrexone can help with benzo addiction. http://international.drugabuse.gov/meetings/abstract-database/result/fn%3D%2526amp%3Bln%3D%2526amp%3Bsub%3D%2526amp%3Byr%3D0%2526amp%3Bcat%3D0%2526amp%3Bco%3D0%2526amp%3Breg%3D0%2526amp%3Bid%3D1829 "The current study, however, indicated that treatment of heroin-dependent persons with a 3.5g - 5g sustained-release naltrexone implant was associated with a decrease in amphetamine, cannabis, or benzodiazepine use over the initial course of treatment while blood naltrexone levels are maintained above 3.8 ng/mL." Im not sure if this discussion has taken place, but I could not find it. Since benzos and alcohol work in the brain very similarly, it would make sense that Naltrexone may help. For more information on how the alcohol cure works, go to: http://en.wikipedia.org/wiki/Sinclair_Method Rumor has it that Dr. Sinclair is working on trials which validate other uses for Naltrexone. As it stands, if you take it WHILE DRINKING, over the course of about a year, it works on brain chemistry (endorphins, etc.) to reduce craving. "Its mechanism of action in this indication is not fully understood, but as an opioid-receptor antagonist is likely to be due to the modulation of the dopamine-mesolimbic pathway which is hypothesized to be a major center of the reward associated with addiction (being one of the primary centers for risk-reward analysis in the brain, and a tertiary "pleasure center") that all major drugs of abuse are believed to activate." Link to comment Share on other sites More sharing options...
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