As some people may know, clonazepam has serotonergic properties.
How that works is very complicated.
Here I'd like to focus on the serotonin transporter. After continuous use clonazepam upregulates the serotonin transporter. It's a bit the opposite of the SSRIs, SSRIs tend to downregulate the serotonin transporter.
I think I'm very sensitive to this particular attribute of this drug. Long story.
Serotonin affects mood, cognition, perception, metabolism, and lots of basic functions for humans, mammals and lower organisms.
Back to the serotonin transporter.
If you wanted to target serotonin that would seem to be the most obvious choice.
It's both a matter of tapering, undoing what clonazepam has done to the serotonin system and to keep it simple.
As far as tapering is concerned, it stands to reason that not all effects of clonazepam (GABA-A, GABA-B, serotonin, glutamate etc.) can be tapered at the same rate !
We're talking about different mechanisms, after all.
Benzos act on the benzodiazepine site on the GABA-A receptor, which is an ion channel, GABAB is a GCPR, and the serotonin transporter (SERT) is a monoamine transporter protein.
While a slow and gradual 'textbook' taper is preferred, that doesn't always work.
A few issues that I have experienced that are at least partly related to 'serotonin', DP/DR, weight gain, perception (taste/color/sound), mood, insomnia (melatonin?), slower/faster metabolism.
When I take a dose of clonazepam time appears to speed up, my appetite and metabolism are affected, when the dose wears off time appears to slow down and I experience a lack of energy.
When I lower the dose (taper) I seem to experience a lack of energy, which can be counteracted to some extent by eating carbohydrates.
For me, clonazepam has both sedating and stimulating properties.
Just some of my issues.
Obviously, taking an SSRI would work. But I'm not depressed, I don't like the weight gain, insomnia and frankly I just wouldn't want to be 'on' a personality changing drug.
What else ?
I know alcohol can have serotonergic properties. Alcohol+clonazepam can be very bad, although it may also have positive properties. Frankly, I'm not sure what this combo does.
It may have some SERT downregulating-properties.
(alcohol acts on both GABAA, GABAB, serotonin and more)
t3 (thyroid) acts on serotonin autoreceptors ...
I'm sure there is lots more.
Any ideas what could be used to downregulate the serotonin transporter, or modulate it in some way ?
l-tryptofan seems to do nothing or cause dysphoria, 5-HTP doesn't do anything.
Choline/serotonin seem to interact.
I hope this makes sense, I have some brain fog. I suppose it doesn't hurt to ask.
Approaching this by means of the serotonin transporter is relatively simple, clonazepam causes both upregulation and downregulation of serotonin, (where?), presynaptic vs. postsynaptyc, involvement of GABAB etc.