Author Topic: Compounded Lorazepam Solutions & Suspensions  (Read 331 times)

[Buddie]

Compounded Lorazepam Solutions & Suspensions
« on: March 25, 2022, 07:09:37 pm »
Here i'm hoping to gain some solution Options for compounded lorazepam
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: Compounded Lorazepam Solutions & Suspensions
« Reply #1 on: March 25, 2022, 08:13:32 pm »
Included below are the formulations Iíve located.  Letís hope other members will share the formulations their compounding pharmacists are using and/or formulations from the pharmaceutical/medical literature.

Commercial 2mg/mL Lorazepam Oral Solution (Concentrate)

In the US, an FDA-approved, commercially manufactured 2mg/mL oral lorazepam solution is currently available from three different manufacturers.  Members typically dilute these solutions with water to achieve lower concentrations.

Compounded Solutions

(1) Stability-tested formulation for 1mg/mL oral solution developed by team of pharmacists in The Netherlands.  Ingredients:

Lorazepam API
Glycerol
Polyethylene glycol 400
Propylene glycol
Orange essence

Citation:
Vossen, A.C. & Velde, I. & Smeets, O.S.N.M. & Postma, D.J. & Eckhardt, M. & Vermes, A. & Koch, Birgit & Vulto, Arnold & Hanff, L.M.. (2017). Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients; lorazepam as a model drug. European Journal of Pharmaceutical Sciences, pp. 205-210. Accessed online at: https://www.sciencedirect.com/science/article/pii/S0928098717300490

(2) Formulation for an oral solution developed by a USP 795/797/800 compliant compounding pharmacy. Ingredients:

Lorazepam API
Propylene glycol USP
Water
Ethyl alcohol 90 proof USP
Sorbitol solution USP 70% w/w
Raspberry flavoring

Compounded Suspensions

(1) 1mg/mL lorazepam oral suspension
https://www.nationwidechildrens.org/-/media/nch/specialties/pharmacy/compounding-formulas/lorazepam--low--oral.ashx

(2) 1mg/mL lorazepam oral suspension
https://www.medisca.net/pdf/shortage-support/en-us/oral/F%20001%20270v2%20Lorazepam%201%20mg%20per%20mL%20Oral%20Liquid.pdf

(3) 0.4mg/mL lorazepam oral suspension
http://inphonet.albertahealthservices.ca/pharmacy/ahs_recipes/viewrecipe.asp?id=75
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.