Author Topic: half lives  (Read 252 times)

[Buddie]

half lives
« on: March 18, 2022, 09:39:20 am »
Can anyone explain why theses drugs are not effective for the duration of 1 half life? For example, temazepam half life average 10 hours yet only ever got 2-3 hours sleep whatever the dose
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[Buddie]

Re: half lives
« Reply #1 on: March 20, 2022, 01:43:22 am »
Some people can be fast metabolizers of specific drugs.

How long have you been taking temazepam? You might have simply built up an enormous tolerance. And the two things can go together - if you take a drug for a long period your body can become more efficient at metabolizing it and you can build significant tolerance, so that the drug is being eliminated more quickly and it doesn't have the same effect due to changes that have occurred to the receptors and other complementary neurotransmitters.

Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.