Author Topic: thinking of switching from dry cutting to water titration  (Read 680 times)

[Buddie]

thinking of switching from dry cutting to water titration
« on: February 03, 2022, 11:36:28 pm »
Hi , I am thinking of switching from dry cutting to water titration.   What is good to use to dissolve lorazepam? I have read propylene glycol, vodka, or just plain water?   I want to dissolve my current daily dose  split it in 2 doses and remove 1 ml of liquid per day.   But not sure how to dissolve the lorazepam. Thank you!!
« Last Edit: February 04, 2022, 12:03:06 am by [Buddie] »
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[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #1 on: February 04, 2022, 01:59:09 am »
I think the safest approach is to obtain a liquid formulation of lorazepam from the pharmacist if one is available where you live.  I think alcohol (e.g. vodka) would be my second choice (100 proof should work better than 80 proof).
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #2 on: February 04, 2022, 02:08:30 am »
Another option to consider is the FDA-approved oral lorazepam solution.

Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #3 on: February 04, 2022, 03:30:34 am »
Thank you for responding!!  I was thinking about the liquid lorazepam but it only comes in 2mg... I am currently at .2mg of lorazapam. I'm not sure how I would do that. I think the lowest amt. on the dropper for the liquid lorazepam is .25mg  and I think with the liquid lorazepam once you mix it with food or water they say you need to take it right away and cannot be stored....  Not sure what to do. If I dissolve my dosage using the vodka and water can that be stored in the fridge for later?
Thank you!!! :)
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #4 on: February 04, 2022, 12:27:13 pm »
We have multiple members who dilute the commercially manufactured oral solutions of their benzodiazepines with water before using them.  If you are interested in specifics, let me know.

To my knowledge, homebrew liquids made with regular lorazepam tablets, vodka, and water have not been tested for stability.  So we donít really know how long they can be stored or if refrigeration is required.  I have read that lorazepam is subject to hydrolysis and should be protected from light; I also know the commercial solution requires refrigeration.  So, to be on the safe side, Iíd probably make small batches (e.g. just enough for a day or perhaps a maximum of 5 days) and keep the homebrew refrigerated.
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #5 on: February 04, 2022, 03:34:05 pm »
There are ways to accurately measure out volumes smaller than 0.1 ml.  An adjustable 100 microliter (0.1 ml) pipet costs around $30-$35 on Amazon.  They're very easy to use, and you could use the adjustable 100 microliter pipet until you were down to 0.02 mg.

Or you can make a dilution using regular syringes as Libs has mentioned.
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #6 on: February 04, 2022, 07:02:07 pm »
Thank you [...] and [...], Both options sound good!!  Will have to figure out which way to go..    :)
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #7 on: February 04, 2022, 09:43:22 pm »
Youíre most welcome, [...].  If you are interested in pursuing the other option [...] suggested (using a compounded liquid), let me know.  I have formulations for two oral lorazepam solutions that are being/have been used successfully by members as well as one for an oral lorazepam suspension.
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #8 on: February 04, 2022, 11:19:23 pm »
If using the vodka to dissolve the lorazepam, how long do I leave the lorazepam in the vodka before I can add the water to the mix.
Thank you!!
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: thinking of switching from dry cutting to water titration
« Reply #9 on: February 05, 2022, 01:15:09 am »
Options...

1) Simply dissolve the lorazepam into 2 ml of vodka then take 1 ml for your two daily doses.  You can make reductions by taking a little less (0.99 ml, 0.98 ml, 0.97 ml...).  I'd let the (crushed) pill sit in the vodka for at least 5 minutes (with gentle agitation).  Everything I've read supports the drug going into solution if you make it like this, but I've not seen it done like this clinically.

2) Dissolve the lorazepam into 2 ml of vodka then dilute into a larger amount of water (e.g. 200 ml).  Then drink half the mixture twice a day.  Again, you reduce your dose by drinking less of the mixture (99 ml, 98 ml, 97 ml, ...).  Again, I'd let the crushed pill sit in the vodka for at least 5 minutes before diluting.  We really have no 'hard' evidence that this mixture is evenly distributed or how long/short it lasts.  But a fair number of people have tried to make liquid formulations like this.

Either way, you take the same amount of vodka (1 ml per dose, initially).  btw - you can use whiskey or rum or cognac or gin if you prefer.  Just make sure it's at least 80 proof (100 proof is better).

If you do a switch to liquid, I'd just switch one dose first and see how it goes for a week or two.
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.