[La...] Posted December 26, 2021 Share Posted December 26, 2021 The full title of this Chinese review is "A network meta-analysis of the long- and short-term efficacy of sleep medicines in adults and older adults". https://pubmed.ncbi.nlm.nih.gov/34560134/ Abstract Background: This study focuses on seven commonly used hypnotics to comprehensively analyze the effects of long- and short-term use on sleep outcomes among adults and older adults. Methods: A network meta-analysis was performed. The insomnia medications were classified into seven categories: benzodiazepines, z-drugs, melatonin, H1-antagonists, orexin receptor antagonists (ORAs), antidepressants, and anticonvulsants. We compared their efficacy of total sleep time, sleep latency, sleep efficiency and wake after sleep onset in subgroups short-term, long-term, elderly, and adults. Results: A total of 111 RCTs involving 25,923 participants were included in this study. Conclusions: ORAs can be widely used in adults and the elderly, and both short-term and long-term use are effective for primary insomnia. H1-antagonists are more effective in adults than in the elderly. Although benzodiazepines have a more obvious effect on sleep maintenance, it is best to reduce their use due to their side effects, especially for the elderly. As a food supplement, melatonin has little effect on adults, but it still has a certain effect on the elderly. Link to comment Share on other sites More sharing options...
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