[La...] Posted December 4, 2021 Share Posted December 4, 2021 The full title of this Argentinian case report is "Zolpidem Dependence and Withdrawal. A Case Report of Generalized Seizures". https://pubmed.ncbi.nlm.nih.gov/34446256/ Abstract Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to withdrawal at a dose of 300mg per day of zolpidem is presented and a brief review of the literature is carried out. Link to comment Share on other sites More sharing options...
[Fi...] Posted December 4, 2021 Share Posted December 4, 2021 The full title of this Argentinian case report is "Zolpidem Dependence and Withdrawal. A Case Report of Generalized Seizures". https://pubmed.ncbi.nlm.nih.gov/34446256/ Abstract Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to withdrawal at a dose of 300mg per day of zolpidem is presented and a brief review of the literature is carried out. 300mg per day?! That's like 30 to 60 times greater than the normal prescribed dosage. Link to comment Share on other sites More sharing options...
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