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Case Report, Aug/21: Zolpidem Dependence and Withdrawal -- generalized seizures


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The full title of this Argentinian case report is "Zolpidem Dependence and Withdrawal. A Case Report of Generalized Seizures".

 

https://pubmed.ncbi.nlm.nih.gov/34446256/

 

Abstract

 

Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to withdrawal at a dose of 300mg per day of zolpidem is presented and a brief review of the literature is carried out.

 

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The full title of this Argentinian case report is "Zolpidem Dependence and Withdrawal. A Case Report of Generalized Seizures".

 

https://pubmed.ncbi.nlm.nih.gov/34446256/

 

Abstract

 

Zolpidem is a non-benzodiazepine hypnotic agent used most frequently in the treatment of insomnia, indicated for short-term use. It is not indicated for the chronic treatment of sleep disorders, despite which there is evidence in clinical practice that a large number of patients receive it for years. Although it has been described that it presents a better profile of adverse effects than benzodiazepines and that it generates a lower risk of dependence and withdrawal than these, there are significant reports of cases of dependence and withdrawal from zolpidem. A report of a case of generalized tonic-clonic seizures due to withdrawal at a dose of 300mg per day of zolpidem is presented and a brief review of the literature is carried out.

 

300mg per day?! That's like 30 to 60 times greater than the normal prescribed dosage.  :idiot:

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