Author Topic: Translocator Protein (TSPO) involvement?  (Read 328 times)

[Buddie]

Translocator Protein (TSPO) involvement?
« on: November 05, 2021, 12:14:12 pm »
Hi All,  I just reviewed the talk given by Dr, Todd Vanderah in this symposium:

Benzodiazepine Withdrawal Symposium
https://www.youtube.com/watch?v=cS9eYKgUUTM
2:28:22   Dr.Todd Vanderah Ongoing benzodiazepine research project at the University of Arizona

I was intrigued by one slide he had re: the translocator protein (TSPO) which was first identified as PBR, peripheral benzodiazepine receptor which is expressed in many tissues outside the brain.

https://en.wikipedia.org/wiki/Translocator_protein

Everyone always talks about GABA receptors being down regulated as the main issue with our withdrawal syndrome, but couldn't the dysregulation of the expression of this protein be another root cause of all our symptoms, especially since it is highly expressed in the adrenals where our stress intolerance stems from?

I didn't see any other recent publications by Dr V on the topic, nor any other research being done. 

Does anyone have an opinion on this, and whether it relates to the NO OH NOO theory??
http://www.benzobuddies.org/forum/index.php?topic=232322.msg2981270#msg2981270


Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: Translocator Protein (TSPO) involvement?
« Reply #1 on: November 05, 2021, 03:29:05 pm »
I see Pamster split out my question from the other thread to its own topic in this section.  Tried to remove as this thread is now redundant, but it seems I cannot....
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: Translocator Protein (TSPO) involvement?
« Reply #2 on: December 26, 2021, 04:25:03 am »
Hi All,  I just reviewed the talk given by Dr, Todd Vanderah in this symposium:

Benzodiazepine Withdrawal Symposium
https://www.youtube.com/watch?v=cS9eYKgUUTM
2:28:22   Dr.Todd Vanderah Ongoing benzodiazepine research project at the University of Arizona

I was intrigued by one slide he had re: the translocator protein (TSPO) which was first identified as PBR, peripheral benzodiazepine receptor which is expressed in many tissues outside the brain.

https://en.wikipedia.org/wiki/Translocator_protein

Everyone always talks about GABA receptors being down regulated as the main issue with our withdrawal syndrome, but couldn't the dysregulation of the expression of this protein be another root cause of all our symptoms, especially since it is highly expressed in the adrenals where our stress intolerance stems from?

I didn't see any other recent publications by Dr V on the topic, nor any other research being done. 

Does anyone have an opinion on this, and whether it relates to the NO OH NOO theory??
http://www.benzobuddies.org/forum/index.php?topic=232322.msg2981270#msg2981270

Interesting... I'm going to do some research into this.

Thanks for the info
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.