[La...] Posted August 19, 2021 Share Posted August 19, 2021 The full title of this New Zealand/Canadian review is "Remimazolam: a short-acting benzodiazepine for procedural sedation". https://pubmed.ncbi.nlm.nih.gov/34061128/ Abstract The ultra-short-acting opioid analgesic remifentanil provided the approach that was used in the synthesis of remimazolam. A carboxylic ester was incorporated into the benzodiazepine structure providing a resultant compound that is rapidly broken down in the body into a breakdown product that is inactive, thus ensuring a very short-acting benzodiazepine. Remimazolam is highly selective in its action, only having activity at the GABAA receptor. It has been shown to be highly effective in providing sedation for bronchoscopy and colonoscopy without having a prolonged duration of action, therefore having a short effect until patients are fully awake and ready for discharge. Link to comment Share on other sites More sharing options...
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