Author Topic: what is everyone's thoughts on NMDA antagonists?  (Read 889 times)

[Buddie]

what is everyone's thoughts on NMDA antagonists?
« on: January 09, 2021, 09:38:04 pm »
What does everyone think about using NMDA antagonists. I read this https://www.reddit.com/r/benzorecovery/comments/jye4y6/take_nmda_antagonists_seriously/

and the person said that they experienced very little withdrawal symptoms. What does everyone think?
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #1 on: January 09, 2021, 10:32:47 pm »
I am very curious as well. I see riluzole reviews on drugs.com for OCD and if it works for benzo taper/wd then I would be solving two things at once.
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #2 on: January 10, 2021, 10:11:47 am »
Research shows that NDMA antagonists during benzodiazepine withdrawal can prevent withdrawal symptoms, that is true. However, NDMA antagonists are unpleasant in and of themselves, dissociation is not a pleasant feeling. Also, you are switching dependency on one drug for dependency on another.
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #3 on: January 10, 2021, 04:28:46 pm »
[...],

I've heard that some people take ketamine for fun. I may have tried it myself in my past. I can see how it might help with depression. I think people should be prepared that it might be a "drug experience" with all that is good and bad about that. But if you go in expecting a strong drug experience, you will not be overwhelmed because it's supposedly given at a light dose. The effect is more likely to be relaxing and perhaps slightly peculiar rather than anything difficult. Just my opinion based upon enjoying a moderate dose, if I tried it.

I do have a difficulty with the idea of consuming anything that's produced in a lab unless it's like life or death. I've not even decided if I'm getting this vaccine. The opportunity doesn't present itself and I don't feel like seeking it, so I have no plans to do ketamine again. I don't need to decide if that's a rule I have made but it could be. Once in a blue moon, decades away, who knows? I did quite like it and I do believe it sort of gave me a boost that lasted a while afterwards. It's kinda hard to know that because I was in such a horrible state. I was beyond being snapped out of it completely by a one off administration of any drug. Rock bottom gave me the opportunity to explore and experiment. It was just survival mixed with escapism.

I think that anybody who has to be in control at all times might not like it. If you can believe it's going to help you, it probably will. I intuitively understand the mechanism by which it works. It'll be fine if you're not panicking.

I've thought of trying gingko biloba. I read something about this sort of effect but I haven't been sufficiently moved to make a purchase. I suppose it's because I'm actually feeling alright most of the time.  :thumbsup:
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #4 on: January 10, 2021, 04:30:34 pm »
Research shows that NDMA antagonists during benzodiazepine withdrawal can prevent withdrawal symptoms, that is true. However, NDMA antagonists are unpleasant in and of themselves, dissociation is not a pleasant feeling. Also, you are switching dependency on one drug for dependency on another.

Mementine, mentioned on that list, has all kinds of side effects. My provider let me try half a 5 mg pill, it caused GI upset and worse, it caused insomnia. It can also cause sleepynesss so I was hoping it would help me with sleep.. I gave up after almost 3 weeks using 2.5 mg. BB user Mamoot has had success with it, but did stop it earlier in his taper, and restarted it later. One study read said it is best to use it starting day 4 after stopping your Benzo, and taking it until day 21 (at 5 mg). Supposedly it reduced or eliminated acute in those in the study. YMMV.
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #5 on: January 10, 2021, 04:44:35 pm »
[...],

I've heard that some people take ketamine for fun. I may have tried it myself in my past. I can see how it might help with depression. I think people should be prepared that it might be a "drug experience" with all that is good and bad about that. But if you go in expecting a strong drug experience, you will not be overwhelmed because it's supposedly given at a light dose. The effect is more likely to be relaxing and perhaps slightly peculiar rather than anything difficult. Just my opinion based upon enjoying a moderate dose, if I tried it.

I do have a difficulty with the idea of consuming anything that's produced in a lab unless it's like life or death. I've not even decided if I'm getting this vaccine. The opportunity doesn't present itself and I don't feel like seeking it, so I have no plans to do ketamine again. I don't need to decide if that's a rule I have made but it could be. Once in a blue moon, decades away, who knows? I did quite like it and I do believe it sort of gave me a boost that lasted a while afterwards. It's kinda hard to know that because I was in such a horrible state. I was beyond being snapped out of it completely by a one off administration of any drug. Rock bottom gave me the opportunity to explore and experiment. It was just survival mixed with escapism.

I think that anybody who has to be in control at all times might not like it. If you can believe it's going to help you, it probably will. I intuitively understand the mechanism by which it works. It'll be fine if you're not panicking.

I've thought of trying gingko biloba. I read something about this sort of effect but I haven't been sufficiently moved to make a purchase. I suppose it's because I'm actually feeling alright most of the time.  :thumbsup:
The way they did it in lab isn't something you'd be able to do at home. They put the rats under ketamine anesthesia and then flumazenil benzos out of them. You can take memantine at home, but doses required would be something like 30 mg / day and then you'd have problem of how to get off memantine.
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #6 on: January 10, 2021, 04:46:38 pm »
Anything on Agmatine?  I only see 2 posts on it

https://examine.com/supplements/agmatine/
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #7 on: January 10, 2021, 04:59:15 pm »
It seems to me as if you’d just be trading one drug for another. So you’d still be taking a medication every day. Which would be yet again another withdrawal to go through. Doesn’t se worth it to me. I’d rather just tough it out.
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #8 on: January 10, 2021, 09:20:23 pm »
Anything on Agmatine?  I only see 2 posts on it

https://examine.com/supplements/agmatine/
The problem is dosing. How do you dose agmatine?
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[Buddie]

Re: what is everyone's thoughts on NMDA antagonists?
« Reply #9 on: January 10, 2021, 10:28:19 pm »
But regarding riluzole, are there reports about wd or issues on long term use? I read an post on IOCD that it is studied as a new drug for OCD. If this helps, I will be happy to take it instead of SSRIs.
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