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Adverse reactions of benzodiazepines


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Side effect

From the nervous system (especially in elderly patients): often - drowsiness, increased fatigue, dizziness, decreased ability to concentrate, ataxia (unsteadiness of gait and poor coordination of movements, leading to loss of balance), disorientation, lethargy, muscle atony, dullness of emotions , slowing down of mental and motor reactions; infrequently - headache, euphoria, depression, tremors, depression of mood,

catalepsy, amnesia, confusion, dystonic extrapyramidal reactions (uncontrolled body movements, including the eyes), myasthenia gravis during the day, dysarthria; very rarely - paradoxical reactions (aggressive outbursts, fear, suicidal tendencies, muscle spasm, confusion, hallucinations, acute agitation, irritability, anxiety, insomnia

From the side of the organ of vision: infrequently - visual impairment (diplopia).

 

From the hematopoietic system: infrequently - leukopenia, neutropenia, agranulocytosis (chills, hyperthermia, sore throat, excessive fatigue, or weakness), anemia, thrombocytopenia.

 

From the digestive system: often - dryness of the oral mucosa or salivation; infrequently - heartburn, nausea and / or vomiting, decreased appetite, constipation or diarrhea; impaired liver function, increased activity of hepatic transaminases, lactate dehydrogenase and alkaline phosphatase, jaundice.

 

From the urinary system: rarely - urinary incontinence, urinary retention, impaired renal function.

 

From the reproductive system: rarely - impaired or decreased libido, dysmenorrhea.

 

Allergic reactions: skin rash (including erythematosis, urticaria), itching; very rarely - anaphylactic reactions.

 

Influence on the fetus: teratogenicity, respiratory failure and suppression of the sucking reflex in newborns whose mothers used lorazepam.

 

Others: addiction, drug dependence, lowering blood pressure; rarely - depression of the respiratory center, bulimia, weight loss, tachycardia; very rarely - angioedema, inadequate secretion of antidiuretic hormone.

 

Pri rezkom snizhenii dozy ili prekrashchenii priyema vozmozhno razvitiye sindroma "otmeny" (razdrazhitel'nost', golovnaya bol', trevozhnost', volneniye, vozbuzhdeniye, chuvstvo strakha, nervoznost', narusheniya sna, disforiya, spazm gladkikh myshts vnutrennikh organov i skeletnoy muskulatury, mialgiya, depersonalizatsiya, isparina, usileniye potootdeleniya, depressiya, toshnota, rvota, tremor, rasstroystva vospriyatiya, v t.ch. giperakuziya, parestezii, svetoboyazn', takhikardiya, sudorogi, gallyutsinatsii, redko - ostryy psikhoz).

With a sharp decrease in the dose or discontinuation of the intake, it is possible to develop a withdrawal syndrome (irritability, headache, anxiety, excitement, excitement, fear, nervousness, sleep disturbances, dysphoria, spasm of smooth muscles of internal organs and skeletal muscles, myalgia, depersonalization, perspiration, increased sweating, depression, nausea, vomiting, tremors, perception disorders, including hyperacusis, paresthesia, photophobia, tachycardia, convulsions, hallucinations, rarely acute psychosis).

 

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