Study Shows High Dose Vitamin B1 (Thiamine) Helps Alleviate PAWS damage

I am reading a study that shows that Vitamin B1 (Thiamine) and its derivative benfotiamine in high doses can help normalize sensitized AMPA receptors that were exposed to stress. Apart from damage done to GABA receptors, benzos can also permanently sensitize the glutamergic AMPA receptors. This is a key cause of many benzo PAWS related sleep issues, especially excess REM sleep and sleep maintenance insomnia. AMPA and NDMA antagonists increase REM sleep and block the body's ability to go into deep sleep.

I am wondering what are people's thoughts about this? Apart from kindling caused by excess glutamate, WD causes a significant disruption of the HPA axis and a huge amount of stress which would further sensitize AMPA receptors. Has anyone had any bad reactions to vitamin B1?

"Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice "

https://pubmed.ncbi.nlm.nih.gov/30817932/