[Te...] Posted February 26, 2020 Share Posted February 26, 2020 I saw this article: https://link.springer.com/article/10.1007/s00213-019-5185-8 I admit I didn't read it all, just scanned a bit of it. But it seems that good health begins in the gut, and I don't doubt that drugs can cause damage to the gut. If anyone has any links, you can post them here. Link to comment Share on other sites More sharing options...
[Fi...] Posted February 27, 2020 Share Posted February 27, 2020 A link which mentions alprazolam, neurotransmitters & the gut biome (I have no personal knowledge in regard to safety or efficacy): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772764/ "Neurotransmitters: The critical modulators regulating gut-brain axis" Link to comment Share on other sites More sharing options...
Guest [Sk...] Posted February 27, 2020 Share Posted February 27, 2020 https://www.genomeweb.com/sequencing-technology/gut-microbiome-makeup-influenced-medication-use-other-factors#.XldDY5Mzb Gut Microbiome Makeup Influenced by Medication Use, Other Factors Antibiotic use, particularly of β-lactams, affected what was present in the gut microbiome, but so did benzodiazepines, antidepressants, and antihistamines, the researchers found. Some 63 percent of the covariate interactions they detected were driven by medication, suggesting that medication use should be taken into account in clinical studies. https://www.gutmicrobiotaforhealth.com/en/scientists-succeed-in-deciphering-microbiome-contributions-to-drug-metabolism/ In order to explore the general nature of these findings, the researchers also studied how gut bacteria contribute to the metabolism of two other drugs: antiviral drug sorivudine and anti-anxiety drug clonazepam. It was discovered that gut bacteria play a considerable role in circulating toxic metabolites derived from these drugs. In the case of clonazepam, the microbiota contributes up to 78% of the circulating aminoclonazepam, whereas it contributes up to 66% of aminohydroxyclonazepam, which is a metabolite generated by both microbial and host enzymes. In conclusion, the host gut microbiota is an important contributor to circulating toxic metabolites of certain drugs such as antivirals brivudine and sorivudine and anti-anxiety drug clonazapem. These findings are a step forward in understanding which drugs should be given to a patient in order to minimize their toxic side effects and also opens up the option of manipulating the gut microbiome to achieve an enhanced therapeutic response. Link to comment Share on other sites More sharing options...
[to...] Posted February 27, 2020 Share Posted February 27, 2020 Wow. Very interesting information. This is probably why I've had such a positive response to probiotics. Link to comment Share on other sites More sharing options...
[Aj...] Posted February 27, 2020 Share Posted February 27, 2020 I had perfect gut health for 20 years on diazepam. Never any problems at all. WD has destroyed it. Link to comment Share on other sites More sharing options...
[Ca...] Posted February 27, 2020 Share Posted February 27, 2020 Following.. Link to comment Share on other sites More sharing options...
[no...] Posted February 27, 2020 Share Posted February 27, 2020 Benzodiazepines are well known to cause Dysbiosis as do antibiotics and other drugs https://en.wikipedia.org/wiki/Dysbiosis From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4879184/ Nova xxx :smitten: :smitten: Link to comment Share on other sites More sharing options...
[Te...] Posted February 27, 2020 Author Share Posted February 27, 2020 Thanks so much for the information! I'll have to read up on it. I believe the gut is the seat of all our health problems. More studies need to be done on this and the effects the pills have on the delicate gut microbiome. Thinking of benzo belly - certainly it seems to me that it means a disruption in the gut microbiome. This, too, needs to be studied. Link to comment Share on other sites More sharing options...
[Ca...] Posted February 27, 2020 Share Posted February 27, 2020 I have NO doubt that for ME even a small (initiation) dose of probiotics give the effect of stripping out my oxycontin SR somewhere through its pathway..!!?? Thankfully I have also seen some substantial improvements too, -particularly with my deep, entrenched SX like initiation motivation and drive.. ie. LIFE... Upside down and inside out atm here..!! Im realising that just because I have a poor initiation response to some things eg mag and calcium etc. -they may actually be things I need, or are good for me in the longer term.. Link to comment Share on other sites More sharing options...
[Te...] Posted February 28, 2020 Author Share Posted February 28, 2020 True, cantfly. I've wanted to take magnesium but have been scared to because of reactions. What type of probiotic do you use? I used one for awhile, and also drank kefir, and I didn't get good results. Link to comment Share on other sites More sharing options...
[Ca...] Posted February 28, 2020 Share Posted February 28, 2020 True, cantfly. I've wanted to take magnesium but have been scared to because of reactions. What type of probiotic do you use? I used one for awhile, and also drank kefir, and I didn't get good results. Biome Lift -by Activated Probiotics.. Its aimed at serotonin and dopamine production, apparently.. I didnt notice much of anything from a cheaper one, perhaps some rough days if I look back, but this one was near instant, both good and bad, so I have slowed the initiation right down.. -with that the good dropped off too.. -Getting there.. I noticed I can tolerate basic supplements a little better these days too, -pretty small doses though.. Atm, im exploring combination rather than one at a time.. Some say its important..?? Link to comment Share on other sites More sharing options...
[Te...] Posted February 28, 2020 Author Share Posted February 28, 2020 Oh, that's right. I seemed to have read about it on another post. I'm scared of taking probiotics, though. It seems that we're all different and require different probiotics. I just don't know which one would be right for me. Thank you, though, Cantfly! Link to comment Share on other sites More sharing options...
[Ca...] Posted February 28, 2020 Share Posted February 28, 2020 Oh, that's right. I seemed to have read about it on another post. I'm scared of taking probiotics, though. It seems that we're all different and require different probiotics. I just don't know which one would be right for me. Thank you, though, Cantfly! Yeah, I just did a bit if a “That sounds good to me”, thing... I hope to fine tune things on the fly.. Iv seen some of your recent posts too, and sure understand your hesitation to play with things that could make it worse at this point.. -Give it time... Link to comment Share on other sites More sharing options...
[Te...] Posted February 28, 2020 Author Share Posted February 28, 2020 Thank you, Cantfly! Link to comment Share on other sites More sharing options...
[Ca...] Posted March 2, 2020 Share Posted March 2, 2020 I found this.. -for those that would rather watch than read.. Link to comment Share on other sites More sharing options...
Guest [Sk...] Posted March 2, 2020 Share Posted March 2, 2020 I found this.. -for those that would rather watch than read.. great video thanks Cant saw this in the comments, made me laugh. Brain: I control everything Gut: Hold my bacteria Link to comment Share on other sites More sharing options...
[Ca...] Posted March 3, 2020 Share Posted March 3, 2020 I found this.. -for those that would rather watch than read.. great video thanks Cant saw this in the comments, made me laugh. Brain: I control everything Gut: Hold my bacteria lol, yeah, -Who the Boss..!! Ta for watchng.. Did you notice any obvious holes or lack of clarity in his thoughts..?? -I didnt, which really has me thinking about a few things around here... (Brain fried thinking -that is..) Link to comment Share on other sites More sharing options...
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