Author Topic: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?  (Read 1036 times)

[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #10 on: March 02, 2020, 02:48:41 pm »
Hi there! Please see these directions. They are for pharmacists compounding tablets into liquid suspension. I can help with equivalency questions. (I apologize for that URL but it is a direct download for a PDF.)

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=2ahUKEwjVw7Od_PvnAhWonuAKHdDfBSMQFjAAegQIBhAB&url=https%3A%2F%2Fwww.nationwidechildrens.org%2F-%2Fmedia%2Fnch%2Fspecialties%2Fpharmacy%2Fcompounding-formulas%2Fclonazepam-oral.ashx&usg=AOvVaw1RJ7p3K-IfKlA0BJHra-U_
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[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #11 on: March 02, 2020, 04:54:41 pm »
Thank you and welcome, [...]!

Here is a (somewhat :) ) shorter version of a link to the formulation from Nationwide Childrenís Hospital for a 0.1mg/mL compounded clonazepam suspension:

https://www.nationwidechildrens.org/-/media/nch/specialties/pharmacy/compounding-formulas/clonazepam-oral.ashx

[...]
« Last Edit: March 03, 2020, 06:25:12 pm by [Buddie] »
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #12 on: June 07, 2020, 05:49:22 pm »
[...], have you been able to compound your own Klonopin suspension yet?  If so, how has it been working out for you? 

After reading how disappointed some members have been in their pharmacies' compounded Klonopin suspensions, my partner is leery of going that route.  But unless I'm misinterpreting the compounding method linked in this thread, I see where some Klonopin might be getting lost in the process.
 
The method calls for gradually mixing the diluent into the powder, then transferring the resulting suspension into a calibrated flask and bringing to volume.  Nowhere does the method call for quantitative transfer, which ensures that as much active ingredient as possible is transferred to the flask before bringing the suspension to volume.

Performing a quantitative transfer means that, after the bulk of the suspension is transferred from the mortar to the calibrated flask, the mortar is rinsed with a few ml of diluent, and the rinse is transferred to the calibrated flask.  The rinse step should be performed at least one more time, and if, after that, tablet residue is actually visible in the mortar, additional rinsing will be necessary, the goal being to transfer 100% of the active ingredient to the flask without exceeding the target volume called for in the method.  The rinsing process should also include any other lab ware that may harbor tablet or suspension residue, including the pestle, stirring rod, etc.

According to product literature, Ora-Plus is "thixotropic"--a term I had to look up.  It apparently means that, upon agitation, the product behaves as a liquid but otherwise behaves as a gel. So "rinsing" might be more complicated that it sounds.  However, leaving 5% or more of the Klonopin behind as residue on your lab ware means that your solution, when brought to volume, will be more dilute than the theoretical concentration you're shooting for.  So it's important to strive for 100% transfer of active ingredient without exceeding the final volume to which the flask is calibrated.

Sounds like compounding your own suspension with Ora-Plus might take a little practice, but eventually it should be possible to develop a consistent technique for quantitatively transferring the suspension.       

Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #13 on: June 10, 2020, 07:32:00 pm »
Koko. I managed to find another place, that didn't gouge me,  I went from 3 months of paying
83 dollars every 14 days,  to one place, with one price, and a much larger bottle of 0.1MG/ML
suspension , 150 mls for 55 dollars , currently down to 0.16 (from 0.28 in January) almost
at a quarter of a 0.5 mg actual pill, ( which is 0.125 ) getting there,, taper's  is at day 724 now
( from original start dose of 1.5 mg's of Klonopin) started June 18th 2018 
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #14 on: June 10, 2020, 09:17:14 pm »
Awesome, HappyOne, you found comparable quality at a better price, and you're progressing with your taper!     :balloon:

I, on the other hand, was quoted $48 for 90 ml of 0.1 mg/mL suspension.  Meh.   
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: is DIY tapering Klonopin using Ora-Plus and Ora Sweet possible?
« Reply #15 on: April 12, 2022, 05:58:52 am »
This is a great thread! I love benzo buddies! After reading, I plan to compound my own Klonopin next time instead of having the pharmacy do it. Doing it myself will not only save me the trip, but also prevent me from being stressed about only having 3 compounding refills. I worry that I might be tapering so slowly that Iíll need more than three. I see that I can purchase the 473ml of the Ora-plus for about $28. The same cost for the Ora-sweet. Who knew that compounding would be so easy!


Hope that you are doing well HappyOne!
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.