[th...] Posted October 7, 2019 Share Posted October 7, 2019 Was prescribed this for back pain. Anybody have an experience with it? Link to comment Share on other sites More sharing options...
[Iw...] Posted October 7, 2019 Share Posted October 7, 2019 I believe that it’s an anti inflammatory. I’ve never taken it but it was prescribed to my dog for her back issues a couple years back. Link to comment Share on other sites More sharing options...
[th...] Posted October 7, 2019 Author Share Posted October 7, 2019 I believe that it’s an anti inflammatory. I’ve never taken it but it was prescribed to my dog for her back issues a couple years back. Yes, it is an NSAID. Maybe I'm just paranoid. Link to comment Share on other sites More sharing options...
[th...] Posted October 8, 2019 Author Share Posted October 8, 2019 Anyone? Link to comment Share on other sites More sharing options...
[so...] Posted October 8, 2019 Share Posted October 8, 2019 “γ-aminobutyrate (GABA) is a crucial inhibitory neurotransmitter in the mammalian peripheral nervous system (PNS) and central nervous system (CNS) (1). ... Accumulating evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) modulate GABAA receptor function in heterologous expression systems (6).Mar 15, 2016” Link to comment Share on other sites More sharing options...
[th...] Posted October 8, 2019 Author Share Posted October 8, 2019 “γ-aminobutyrate (GABA) is a crucial inhibitory neurotransmitter in the mammalian peripheral nervous system (PNS) and central nervous system (CNS) (1). ... Accumulating evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) modulate GABAA receptor function in heterologous expression systems (6).Mar 15, 2016” Hi sofakingdone, So, what does that mean in practical terms? Link to comment Share on other sites More sharing options...
[be...] Posted October 8, 2019 Share Posted October 8, 2019 Was prescribed this for back pain. Anybody have an experience with it? It can cause a heart attack or a stroke. IMO bad news. https://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138 Link to comment Share on other sites More sharing options...
[th...] Posted October 8, 2019 Author Share Posted October 8, 2019 Was prescribed this for back pain. Anybody have an experience with it? It can cause a heart attack or a stroke. IMO bad news. https://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138 Hi benzogirl, how are you doing? Thanks for the article. I was more thinking about this drug and brain healing. Not sure there is an answer out there. "Modulation" is ambiguous. Link to comment Share on other sites More sharing options...
Guest [so...] Posted October 8, 2019 Share Posted October 8, 2019 Sofa is right, i wouldn't touch it irrespective of brain issues. Link to comment Share on other sites More sharing options...
[th...] Posted October 8, 2019 Author Share Posted October 8, 2019 Sofa is right, i wouldn't touch it irrespective of brain issues. What do you mean "is right"? Sofa's post just states that it "modulates" which doesn't tell you if it is good or bad. I take the occasional Advil also, which is an NSAID and it doesn't seem to have any negative effects. Link to comment Share on other sites More sharing options...
[Iw...] Posted October 8, 2019 Share Posted October 8, 2019 “γ-aminobutyrate (GABA) is a crucial inhibitory neurotransmitter in the mammalian peripheral nervous system (PNS) and central nervous system (CNS) (1). ... Accumulating evidence suggests that non-steroidal anti-inflammatory drugs (NSAIDs) modulate GABAA receptor function in heterologous expression systems (6).Mar 15, 2016” What exactly does modulates mean? Should I be concerned about it prolonging my withdrawal process? I deal with all over body pain Link to comment Share on other sites More sharing options...
Guest [so...] Posted October 8, 2019 Share Posted October 8, 2019 Research shows that use of NSAIDS has an adverse effect on the heart. I would send links to these studies but don't have access to them atm as I'm having to use my phone to post. Link to comment Share on other sites More sharing options...
[be...] Posted October 8, 2019 Share Posted October 8, 2019 Was prescribed this for back pain. Anybody have an experience with it? It can cause a heart attack or a stroke. IMO bad news. https://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138 Hi benzogirl, how are you doing? Thanks for the article. I was more thinking about this drug and brain healing. Not sure there is an answer out there. "Modulation" is ambiguous. I’m just zippy thanks. Insomnia is a bugger though. I hope you are well. Link to comment Share on other sites More sharing options...
[Pu...] Posted October 8, 2019 Share Posted October 8, 2019 I was on meloxicam for osteoarthritis. It’s like Advil on steroids. Had to stop because it tore up my stomach. Link to comment Share on other sites More sharing options...
[so...] Posted October 8, 2019 Share Posted October 8, 2019 TST, I thought it best to just copy and paste the text from the site because I have no idea what they mean by modulate either. Sofa Link to comment Share on other sites More sharing options...
[so...] Posted October 8, 2019 Share Posted October 8, 2019 Penny, I can’t take NSAIDS because I had a gastric bypass. The surgeon said “no more NSAIDS. It tears up your stomach.” Sofa Link to comment Share on other sites More sharing options...
[...] Posted October 8, 2019 Share Posted October 8, 2019 If you take Advil and you’re fine, meloxicam will be fine. But if Advil doesn’t help, it’s unlikely meloxicam will do anything better. Yes, there’s some small experimental data in rats, maybe not even in rats but in slices of rat brain, that show NSAIDs can inhibit gaba to a minor extent. Is that clinically relevant in humans, who the hell knows, but doubtful, or NSAIDs would give everyone panic attacks (they don’t). There is a vast difference between a cell culture study or rat brain slice in a bench and effects on the human brain. Try yoga, heat, magnesium. Likely to be more helpful. Link to comment Share on other sites More sharing options...
Guest [so...] Posted October 9, 2019 Share Posted October 9, 2019 Most meds are ok for people who don't have a compromised cns eg compromised by bwd. I've just been taking aspirin and wondered why i was having a severe uptick in sxs, I'd taken it before bwd with no problems. After researching it's mode of action i found out that its metabolites have a dysregulating effect on gaba. I've stopped the aspirin and the sxs have stopped. Link to comment Share on other sites More sharing options...
[th...] Posted October 9, 2019 Author Share Posted October 9, 2019 If you take Advil and you’re fine, meloxicam will be fine. But if Advil doesn’t help, it’s unlikely meloxicam will do anything better. Yes, there’s some small experimental data in rats, maybe not even in rats but in slices of rat brain, that show NSAIDs can inhibit gaba to a minor extent. Is that clinically relevant in humans, who the hell knows, but doubtful, or NSAIDs would give everyone panic attacks (they don’t). There is a vast difference between a cell culture study or rat brain slice in a bench and effects on the human brain. Try yoga, heat, magnesium. Likely to be more helpful. Hi ICAN, Thank you for that! Link to comment Share on other sites More sharing options...
[Po...] Posted October 17, 2019 Share Posted October 17, 2019 I just started on Meloxicam today. Dr. prescribed 15mg per day but I'm starting with a quarter of a pill and I'll increase if I can tolerate it and if it seems to work. I'll update if I have anything to report. The listed side effects are pretty scary. I'm currently having trouble sleeping but I think it's mostly due to pain. Sure hoping this stuff works! I've been taking 600mg of ibuprofen 3x per day for hip and shoulder pain and it doesn't help (but I have no side effects, as far as I can tell.) Link to comment Share on other sites More sharing options...
[la...] Posted October 30, 2019 Share Posted October 30, 2019 I take Meloxicam for back pain and I have had no problems with it. Better to take Meloxicam and ditch the Advil, especially if it's not working. Link to comment Share on other sites More sharing options...
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