How many mLs of Everclear 151 to dissolve 1 mg of clonazepam?

According to Jouyban et al’s (2008) data on the solubility of clonazepam in ethanol and water mixtures (see table below and citation below),  one can dissolve 0.6 mg of clonazepam in 1 milliliter of 40% alcohol.

 

In contrast, one can dissolve 6.18 mg of clonazepam in 1 milliliter of 90% alcohol. 

 

Unfortunately, Everclear 180 (90% alcohol) is not sold in all states in the U.S.  However,  Everclear 151 (75.5% alcohol) is more widely available.

 

How many milliliters of Everclear 151 should be used to dissolve 1 mg of clonazepam?  (I’ve searched BenzoBuddies and found recommendations to use 1 mL of Everclear 190 to dissolve 1 mg of clonazepam but did not find a recommendation for Everclear 151.)

 

Units = mg/ml

% Alc.  V          A        Lib      K          X

0        0.04    0.05    0.11    0.03    0.04

10      0.11    0.11    0.19    0.04 

20      0.21    0.23    0.29    0.08

30      0.57    0.77    0.80    0.20

40      1.90    3.51    2.89    0.60

50      4.76    4.19    7.48    1.43

60    11.17    8.04    12.48    2.64

70    21.31  13.09    22.89    4.22

80    28.67  17.33    31.81    5.65

90    38.36    6.64    31.72    6.18

100  26.07  10.89    19.46    5.11

 

K = Klonopin, the brand name for clonazepam

 

Source:

Ali Shayanfar, Mohammad A. A. Fakhree, William E. Acree , Jr. and Abolghasem Jouyban. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, J. Chem. Eng. Data, 2009, 54 (3), pp 1107–1109, December 22, 2008.

 

 

According to Jouyban et al’s (2008) data on the solubility of clonazepam in ethanol and water mixtures (see table below and citation below),  one can dissolve 0.6 mg of clonazepam in 1 milliliter of 40% alcohol.

 

In contrast, one can dissolve 6.18 mg of clonazepam in 1 milliliter of 90% alcohol. 

 

Unfortunately, Everclear 180 (90% alcohol) is not sold in all states in the U.S.  However,  Everclear 151 (75.5% alcohol) is more widely available.

 

How many milliliters of Everclear 151 should be used to dissolve 1 mg of clonazepam?  (I’ve searched BenzoBuddies and found recommendations to use 1 mL of Everclear 190 to dissolve 1 mg of clonazepam but did not find a recommendation for Everclear 151.)

 

Units = mg/ml

% Alc.  V          A        Lib      K          X

0        0.04    0.05    0.11    0.03    0.04

10      0.11    0.11    0.19    0.04 

20      0.21    0.23    0.29    0.08

30      0.57    0.77    0.80    0.20

40      1.90    3.51    2.89    0.60

50      4.76    4.19    7.48    1.43

60    11.17    8.04    12.48    2.64

70    21.31  13.09    22.89    4.22

80    28.67  17.33    31.81    5.65

90    38.36    6.64    31.72    6.18

100  26.07  10.89    19.46    5.11

 

K = Klonopin, the brand name for clonazepam

 

Source:

Ali Shayanfar, Mohammad A. A. Fakhree, William E. Acree , Jr. and Abolghasem Jouyban. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, J. Chem. Eng. Data, 2009, 54 (3), pp 1107–1109, December 22, 2008.

 

Just wondering what difference it makes as long as the med is dissolving? 0.5 ml's of any strength of alcohol is a very small amount.  I'm confused by the complication of all this. 

<sigh>  It really does NOT need to be complicated!

 

Yes, the solubility does increase as the alcohol purity increases, but it is clearly established that 1mg:2ml of 80 proof liquid works.  So you can always be confident that using a ratio of 1mg:2ml will work.  So why not just use that ratio?

 

For folks that are really obsessed about alcohol, just us PG.

Sometimes a question is just a question! 

 

In reviewing Jouyban’s data, I noticed that the solubility of clonazepam in 1 mL 40% alcohol is significantly less than that of the other benzos.

 

Units = mg/ml

% Alc.  V          A        Lib      K       

40      1.90    3.51    2.89    0.60

 

So I was curious to learn if using a higher proof alcohol would improve solubility and, if so, what amount should be used.

Sometimes a question is just a question! 

 

In reviewing Jouyban’s data, I noticed that the solubility of clonazepam in 1 mL 40% alcohol is significantly less than that of the other benzos.

 

Units = mg/ml

% Alc.  V          A        Lib      K       

40      1.90    3.51    2.89    0.60

 

So I was curious to learn if using a higher proof alcohol would improve solubility and, if so, what amount should be used.

 

~and~

 

According to Jouyban et al’s (2008) data on the solubility of clonazepam in ethanol and water mixtures (see table below and citation below),  one can dissolve 0.6 mg of clonazepam in 1 milliliter of 40% alcohol.

 

In contrast, one can dissolve 6.18 mg of clonazepam in 1 milliliter of 90% alcohol. 

 

Unfortunately, Everclear 180 (90% alcohol) is not sold in all states in the U.S.  However,  Everclear 151 (75.5% alcohol) is more widely available.

 

How many milliliters of Everclear 151 should be used to dissolve 1 mg of clonazepam?  (I’ve searched BenzoBuddies and found recommendations to use 1 mL of Everclear 190 to dissolve 1 mg of clonazepam but did not find a recommendation for Everclear 151.)

 

Units = mg/ml

% Alc.  V          A        Lib      K          X

0        0.04    0.05    0.11    0.03    0.04

10      0.11    0.11    0.19    0.04 

20      0.21    0.23    0.29    0.08

30      0.57    0.77    0.80    0.20

40      1.90    3.51    2.89    0.60

50      4.76    4.19    7.48    1.43

60    11.17    8.04    12.48    2.64

70    21.31  13.09    22.89    4.22

80    28.67  17.33    31.81    5.65

90    38.36    6.64    31.72    6.18

100  26.07  10.89    19.46    5.11

 

K = Klonopin, the brand name for clonazepam

 

Source:

Ali Shayanfar, Mohammad A. A. Fakhree, William E. Acree , Jr. and Abolghasem Jouyban. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, J. Chem. Eng. Data, 2009, 54 (3), pp 1107–1109, December 22, 2008.

 

this is awesome! thank you Libertas for the actual factual data on solubility for clonazepam (and other benzos)!

this answers so many questions, what a great timesaver 

 

you're a very helpful BB 

Nomore .. PLEASE PLEASE do NOT use this table to create your own solution.  Your wisest course is to follow the suggestions you’ve been given. That is, use a 1:2:8 ratio if you are using 40% alcohol or use a 1:1:9 ratio if you are using Everclear 190.

Nomore .. PLEASE PLEASE do NOT use this table to create your own solution. Your wisest course is to follow the suggestions you’ve been given. That is, use a 1:2:8 ratio if you are using 40% alcohol or use a 1:1:9 ratio if you are using Everclear 190.

 

:thumbsup:

Nomore .. PLEASE PLEASE do NOT use this table to create your own solution.  Your wisest course is to follow the suggestions you’ve been given. That is, use a 1:2:8 ratio if you are using 40% alcohol or use a 1:1:9 ratio if you are using Everclear 190.

 

well, i was going to do a solution of 1:1:9 with the 190proof, (or very close to that) ...but are you saying this

PLEASE PLEASE do NOT use this table to create your own solution.

in response to the following comment i made on the errors i found on the table you posted?: (or for a different reason?)

 

According to Jouyban et al’s (2008) data on the solubility of (benzos)...

 

Units = mg/ml

% Alc.  V          A        Lib      K          X

0        0.04    0.05    0.11    0.03    0.04

10      0.11    0.11    0.19    0.04 

20      0.21    0.23    0.29    0.08

30      0.57    0.77    0.80    0.20

40      1.90    3.51    2.89    0.60

50      4.76    4.19    7.48    1.43

60    11.17    8.04    12.48    2.64

70    21.31  13.09    22.89    4.22

80    28.67  17.33    31.81    5.65

90    38.36    6.64    31.72    6.18

100  26.07  10.89    19.46    5.11

 

K = Klonopin, the brand name for clonazepam

 

Source:

Ali Shayanfar, Mohammad A. A. Fakhree, William E. Acree , Jr. and Abolghasem Jouyban. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, J. Chem. Eng. Data, 2009, 54 (3), pp 1107–1109, December 22, 2008.

 

uh oh...

 

i wonder why the table shows a decrease in solubility at 100% alcohol? across the board, the numbers of solubility in 100% alcohol (the last line) drop. also...another error i see is at the 90% mark for "A" Ativan? it goes down from 17.33mg solubility in 80% alcohol to 6.64mg solubility in 90% alcohol. another error is solubility on "L" Librium? look at the lines for 80%,90% and 100% respectively...wonder if it was errors in the book/study, or somehow it got copied over to the post wrong? would you double check?

 

(if the table gets copied correctly, and the data is right, then i can make my 10 day solution using the numbers under the 90% alcohol line for K/clonazepam...showing 6.18mg K/clonazepam soluble per 1ml of 90% alcohol...90% alcohol is almost 95%, as is in 190 proof everclear (or my brand "Mohawk") but i'll wait til you have a chance to double check before i mix anything 

According to Jouyban et al’s (2008) data on the solubility of (benzos)...

 

Units = mg/ml

% Alc.  V          A        Lib      K          X

0        0.04    0.05    0.11    0.03    0.04

10      0.11    0.11    0.19    0.04 

20      0.21    0.23    0.29    0.08

30      0.57    0.77    0.80    0.20

40      1.90    3.51    2.89    0.60

50      4.76    4.19    7.48    1.43

60    11.17    8.04    12.48    2.64

70    21.31  13.09    22.89    4.22

80    28.67  17.33    31.81    5.65

90    38.36    6.64    31.72    6.18

100  26.07  10.89    19.46    5.11

 

K = Klonopin, the brand name for clonazepam

 

Source:

Ali Shayanfar, Mohammad A. A. Fakhree, William E. Acree , Jr. and Abolghasem Jouyban. Solubility of Lamotrigine, Diazepam, and Clonazepam in Ethanol + Water Mixtures at 298.15 K, J. Chem. Eng. Data, 2009, 54 (3), pp 1107–1109, December 22, 2008.

 

uh oh...

 

i wonder why the table shows a decrease in solubility at 100% alcohol? across the board, the numbers of solubility in 100% alcohol (the last line) drop. also...another error i see is at the 90% mark for "A" Ativan? it goes down from 17.33mg solubility in 80% alcohol to 6.64mg solubility in 90% alcohol. another error is solubility on "L" Librium? look at the lines for 80%,90% and 100% respectively...wonder if it was errors in the book/study, or somehow it got copied over to the post wrong? would you double check?

 

(if the table gets copied correctly, and the data is right, then i can make my 10 day solution using the numbers under the 90% alcohol line for K/clonazepam...showing 6.18mg K/clonazepam soluble per 1ml of 90% alcohol...90% alcohol is almost 95%, as is in 190 proof everclear (or my brand "Mohawk") but i'll wait til you have a chance to double check before i mix anything 

 

aha! i looked up the study myself and found:

Abstract

Experimental solubilities of three antiepileptic drugs, that is, lamotrigine, diazepam, and clonazepam in ethanol + water mixtures at 298.15 K were reported. The solubility of drugs was increased with the addition of ethanol, reached the maximum values, and then decreased with further increase in ethanol concentrations. The Jouyban−Acree model was fitted to the data, and the solubilities were reproduced using two previously developed relationships employing a number of the solvent’s and solute’s parameters and the solubility data in monosolvents in which the overall mean deviations (OMDs) of the models were 6.2 %, 22.3 %, and 23.2 %.

 

so Libertas you copied it over just right, it is just that the solubility decreased after a certain point of saturation with the solvent of alcohol at a high rate, differing depending on the particular drug. 

Nomore .. PLEASE PLEASE do NOT use this table to create your own solution.  Your wisest course is to follow the suggestions you’ve been given. That is, use a 1:2:8 ratio if you are using 40% alcohol or use a 1:1:9 ratio if you are using Everclear 190.

 

so if i do:

1mg clonazepam +1ml everclear +9ml H2O,

which makes a solution of 1mg per 10ml

in other words 0.1mg clonazepam per 1ml or

0.1mg/1ml ....

 

does a 10 day supply of this look like:

10mg clonazepam +10ml everclear +90ml H20 = 10mg clonazepam per 100ml for a 10mg/100ml (1mg/10ml = .1mg/1ml ) 

 

and if i got that right then:

how do i figure the math to get my .25mg, .25mg and 0.5mg daily doses?  how many ml of the solution above = .25mg and my later dose of 0.5mg?

(i understand the part about adding the total daily dose of med to the measuring cup and adding H2O to =1 cup & dividing the total 1 cup into 3 doses as 1/4 , 1/4, and 1/2 cup doses)

 

and the next question of course, is: what does the daily schedule reducing at the rate of 1% every 6 weeks look like in numbers?

 

(i had all this figured out using the incorrect math from before, spotted the mistake thx to another BB, and now i'm back to square one, so i really need to get this right. once i get the math perfect, then i just follow the formula to a T and i'll have no more worries aside from making sure i read my syringes right. which i'm pretty good at now, lol!)

<sigh> For folks that are really obsessed about alcohol, just us PG.

 

Scientists observed that 2–15 ml of propylene glycol caused nausea, vertigo and strange sensations. These symptoms disappeared within 6 hours (31Trusted Source).

that source was:https://www.ncbi.nlm.nih.gov/pubmed/657787

"Reactions to peroral propylene glycol."

 

some people don't like adding extra chemicals to a highly sensitive system. some people can tolerate alcohol better. some people don't or can't use the fatty based milks and milk alternatives due to dietary/metabolic issues. also alcohol is the most efficient solvent for benzos.

Just an FYI...

 

PG is the world's most commonly used pharma solvent.

 

In the US, there are 5 Rx liquid benzos.  4 of them use PG as a solvent.  The 5th uses alcohol.

<sigh>  It really does NOT need to be complicated!

 

Yes, the solubility does increase as the alcohol purity increases, but it is clearly established that 1mg:2ml of 80 proof liquid works.  So you can always be confident that using a ratio of 1mg:2ml will work.  So why not just use that ratio?

 

For folks that are really obsessed about alcohol, just us PG

<sigh> For folks that are really obsessed about alcohol, just us PG.

 

Scientists observed that 2–15 ml of propylene glycol caused nausea, vertigo and strange sensations. These symptoms disappeared within 6 hours (31Trusted Source).

that source was:https://www.ncbi.nlm.nih.gov/pubmed/657787

"Reactions to peroral propylene glycol."

 

some people don't like adding extra chemicals to a highly sensitive system. some people can tolerate alcohol better. some people don't or can't use the fatty based milks and milk alternatives due to dietary/metabolic issues. also alcohol is the most efficient solvent for benzos.

 

And that is why I chose alcohol over PG.  I just use a very minute amount and it's never been an issue  for me. I've been doing this for almost two years and the only side effect I have ever had was not sleeping as well... which is a given when you taper off Benzo's and feeling weird whenever I have to take another prescription med. 

<sigh> For folks that are really obsessed about alcohol, just us PG.

 

Scientists observed that 2–15 ml of propylene glycol caused nausea, vertigo and strange sensations. These symptoms disappeared within 6 hours (31Trusted Source).

that source was:https://www.ncbi.nlm.nih.gov/pubmed/657787

"Reactions to peroral propylene glycol."

 

some people don't like adding extra chemicals to a highly sensitive system. some people can tolerate alcohol better. some people don't or can't use the fatty based milks and milk alternatives due to dietary/metabolic issues. also alcohol is the most efficient solvent for benzos.

 

And that is why I chose alcohol over PG.  I just use a very minute amount and it's never been an issue  for me. I've been doing this for almost two years and the only side effect I have ever had was not sleeping as well... which is a given when you taper off Benzo's and feeling weird whenever I have to take another prescription med. 

 

Raquel that's actually very encouraging to hear...i have so much fear about beginning to taper the clonazepam, but when you say it has been fairly smooth for you it gives me courage!  thank you!

<sigh> For folks that are really obsessed about alcohol, just us PG.

 

Scientists observed that 2–15 ml of propylene glycol caused nausea, vertigo and strange sensations. These symptoms disappeared within 6 hours (31Trusted Source).

that source was:https://www.ncbi.nlm.nih.gov/pubmed/657787

"Reactions to peroral propylene glycol."

 

some people don't like adding extra chemicals to a highly sensitive system. some people can tolerate alcohol better. some people don't or can't use the fatty based milks and milk alternatives due to dietary/metabolic issues. also alcohol is the most efficient solvent for benzos.

 

And that is why I chose alcohol over PG.  I just use a very minute amount and it's never been an issue  for me. I've been doing this for almost two years and the only side effect I have ever had was not sleeping as well... which is a given when you taper off Benzo's and feeling weird whenever I have to take another prescription med. 

 

Raquel that's actually very encouraging to hear...i have so much fear about beginning to taper the clonazepam, but when you say it has been fairly smooth for you it gives me courage!  thank you!

 

Awe... you are welcome.  Trust me when I first started I was very scared and hesitant.  I probably bugged poor Builder until he was pulling his hair out.  I've just noticed that once you get in your own taper routine, and get more comfortable with the process and it is so much easier.  The more progress you make the more confident that you get.  You will be fine and it's always good to ask questions... that's what this forum is for.