Author Topic: Benzos are are anticholinergic. What does it mean:  (Read 1566 times)

[Buddie]

Re: Benzos are are anticholinergic. What does it mean:
« Reply #10 on: April 11, 2022, 01:33:31 am »
Benzo withdrawal increases acetylcholine especially in the amygdala(the fear center of the brain)

I was thinking the same and that could reduce dopamine. Do you have a source for it?

Acetylcholine in the accumbens is decreased by diazepam and increased by benzodiazepine withdrawal: a possible mechanism for dependency

Pedro Rada 1, Bartley G Hoebel

Affiliations expand

PMID: 15680263 DOI: 10.1016/j.ejphar.2004.12.016

Full text linksCite

Abstract

Diazepam is a benzodiazepine used in the treatment of anxiety, insomnia and seizures, but with the potential for abuse. Like the other benzodiazepine anxiolytics, diazepam does not increase dopamine in the nucleus accumbens. This raises the question as to which other neurotransmitter systems are involved in diazepam dependence. The goal was to monitor dopamine and acetylcholine simultaneously following acute and chronic diazepam treatment and after flumazenil-induced withdrawal. Rats were prepared with microdialysis probes in the nucleus accumbens and given diazepam (2, 5 and 7.5 mg/kg) acutely and again after chronic treatment. Accumbens dopamine and acetylcholine decreased, with signs of tolerance to the dopamine effect. When these animals were put into the withdrawal state with flumazenil, there was a significant rise in acetylcholine (145%, P<0.001) with a smaller significant rise in dopamine (124%, P<0.01). It is suggested that the increase in acetylcholine release, relative to dopamine, is a neural component of the withdrawal state that is aversive.

https://pubmed.ncbi.nlm.nih.gov/15680263/



Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.

[Buddie]

Re: Benzos are are anticholinergic. What does it mean:
« Reply #11 on: April 11, 2022, 03:14:55 am »
ME ts an awfull condition,  but i dont understand the use of this drug as help.. , and when his brain get affected by this injury from benzodiazepines like t did for us ? .. how its going to be?...
Suggestions, opinions and/or advice provided by the author of this post should not be regarded as medical advice; nor should it substitute for professional medical care. Consult your doctor before making any changes to your medication. Please read our Community Policy Documents board for further information.