how can i get compounded liquid quetiapine in the usa?

has nayone done this or is it too hard  insurance?

this drug is difficult to find info on how to make a well dissolved solution or suspension

need input from others!

In the Uk it is made up especially and the maker won’t catch the insurance issues NOR will my GP

So I dissolve the 25 mg in 10ml weak Gin and stir. Then I take just 9ml of solution to swallow.

Sadly had to stop at 22.5 and update while getting off Diaz. But I have a plan!!

Best wishes

Dick

If you go to a compound pharmacy, you can get a liquid form of Seroquel made.  Here is a sample compound pharmacy "recipe" for Seroquel.

 

http://www.mipedscompounds.org/sites/default/files/standard-formulations/Quetiapine.pdf

 

okay yall, just spent a hundred bucks on amazon ordering all my supplies to make this and hopefully the ingredients are a close enough match that it will turn out well (fingers crossed 3 times!)

 

this is what i got:

 

quetiapine 4g = 4000mg total

25mg pills (160 count)

 

saccharin sodium 100mg

Necta Sweet Saccharin Sugar Substitute 1/4 Grain 1000 Tablets

https://www.amazon.com/gp/product/B000GG5N9G/ref=ppx_yo_dt_b_asin_title_o05_s00?ie=UTF8&psc=1

it says one 1/4 grain tablet has 16.2mgs of sodium saccharin, but it also lists other ingredients: sodium bicarbonate(baking soda)~will it neutralize or reduce potency of the quetiapine in suspension or be neutral? this is a tiny amount, but it alkalyzes ph~, silicon dioxide(already an ingredient in the suspension recipe), povidone(iodine), & modified cellulose gum(a gelling suspension agent)...so i'm not sure what difference if any it will make to the suspension...but the pure saccharin sodium powder in bulk bags was too expensive so we'll see!

 

butylated hydroxytoluene (BHT) 100mg

Life Enhancement Bht Plus 100 Caps by Life Enhancement

https://www.amazon.com/gp/product/B01MRWVRGA/ref=ppx_yo_dt_b_asin_title_o03_s00?ie=UTF8&psc=1

BHT (butylated hydroxytoluene) is FDA approved as an antioxidant preservative additive for edible oils and fats. Each capsule of BHT PlusTM contains 180 mg of BHT plus 80 mg of ascorbyl palmitate, a fat soluble form of Vitamin C.

and there are other ingredients, silicon dioxide(already an ingredient in the suspension recipe) and rice flour(this is a bulking agent and a starch). i dunno how much of these and (the 80mg of) ascorbyl palmitate (vitamin A) are in each capsule, or how they will affect the suspension if at all, but we'll see!

 

silica gel, micronized  3g (silicon dioxide)

MakingCosmetics - Silica - 1.8oz / 50g - Cosmetic Ingredient

https://www.amazon.com/gp/product/B0155MH1T0/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1

 

peppermint oil 3ml

Now Essential Oils, Peppermint Oil, 1-Ounce

https://www.amazon.com/gp/product/B00028MKRQ/ref=ppx_yo_dt_b_asin_title_o02_s00?ie=UTF8&th=1

 

sweet almond oil 100ml

Now Solutions Sweet Almond Oil, 4-Ounce

https://www.amazon.com/gp/product/B000NB9LLA/ref=ppx_yo_dt_b_asin_title_o01_s00?ie=UTF8&th=1

 

then for packaging and dispensing the suspension i got these:

 

Oval Plastic Bottles - 4oz, Amber, CR caps - 12 pcs by AmexDrug

https://www.amazon.com/gp/product/B01GILGKYE/ref=ppx_yo_dt_b_asin_title_o05_s01?ie=UTF8&psc=1

 

Press in Bottle Adapter for Oral Medication Syringe (22mm - 25 Count) by GMS

https://www.amazon.com/gp/product/B00KZ017PC/ref=ppx_yo_dt_b_asin_title_o04_s00?ie=UTF8&th=1

 

Sponix BioRx Oral Syringe - 10 mL - Best for dispensing liquids and oils - Individually Wrapped - 10 pcs by BioRx Laboratories

https://www.amazon.com/gp/product/B01BKV54YE/ref=ppx_yo_dt_b_asin_title_o05_s00?ie=UTF8&psc=1

 

BAXA ExactaMed Oral Liquid Medication Syringe 0.5cc/0.5mL 10/PK Clear Medicine Dose Dispenser With Cap Exacta-Med BAXTER Comar Latex Free by Baxa

https://www.amazon.com/gp/product/B01MTJPD2O/ref=ppx_yo_dt_b_asin_title_o05_s00?ie=UTF8&psc=1

 

if anyone is good with chemistry and can tell me what effect if any the extra ingredients in my supplies may cause to the finished suspension, please educate me!!

 

thanks in advance!

okay so i decided to [glow=red,2,300]modify[/glow] this formula in regards to mg per ml.

the original compounding formula for 40mg per ml total volume: 100ml quetiapine (Seroquel) was:

quetiapine 4g = 4000mg total

25mg pills (160 count)

saccharin sodium 100mg

Necta Sweet Saccharin Sugar Substitute 1/4 Grain 1000 Tablets

one 1/4 grain tablet has 16.2mgs of sodium saccharin

butylated hydroxytoluene (BHT) 100mg

Life Enhancement Bht Plus 100 Caps by Life Enhancement

Each capsule of BHT PlusTM contains 180 mg of BHT

silica gel, micronized  3g (silicon dioxide)

MakingCosmetics - Silica - 1.8oz / 50g - Cosmetic Ingredient

peppermint oil 3ml

Now Essential Oils, Peppermint Oil, 1-Ounce

sweet almond oil 100ml

Now Solutions Sweet Almond Oil, 4-Ounce

...but i found out it was really hard to measure out the correct doses on my tapering schedule with the syringes, so i changed the formula by multiplying the amounts of everything except for the quetiapine pills by four...so now it looks like this:

quetiapine 4g = 4000mg total  (left this part the same)

25mg pills (160 count) (just counted my pills and realized i have way more 50mg pills than 25mg pills so i changed this part to 50mg pills (80 count)

saccharin sodium 400mg

Necta Sweet Saccharin Sugar Substitute 1/4 Grain 1000 Tablets

one 1/4 grain tablet has 16.2mgs of sodium saccharin (25 tabs=405mg)

butylated hydroxytoluene (BHT) 400mg

Life Enhancement Bht Plus 100 Caps by Life Enhancement

Each capsule of BHT PlusTM contains 180 mg of BHT (2 & 1/4 capules = 405mg)

silica gel, micronized  12g (silicon dioxide)

MakingCosmetics - Silica - 1.8oz / 50g - Cosmetic Ingredient (12g = .4 oz)

peppermint oil 12ml

Now Essential Oils, Peppermint Oil, 1-Ounce (12ml = .4oz)

sweet almond oil 400ml

Now Solutions Sweet Almond Oil, 4-Ounce (400ml = 13.5oz) about 3/4 of a 16oz bottle

...so now each batch will be made up as 400ml liquid suspension in 4 of the 100ml pharmacy bottles i bought, a total of 53 day supply.

so now instead of 40mg per ml of liquid compounded suspension, (if i did my math right), it will be 10mg per ml of liquid compounded suspension.

SO MUCH EASIER TO MEASURE OUT DOSES!

quetiapine 4g = 4000mg total in 400ml liquid suspension mixture

(in other words 4000mg per 400ml, or  40:4 or 10:1 =10mg/1ml)

10mg =1ml

9mg = .9ml

8mg = .8ml

7mg = .7ml

6mg = .6ml

5mg = .5ml

4mg = .4ml

3mg = .3ml

2mg = .2ml

1mg = .1ml

.9mg= .09ml

.8mg= .08ml

etc...

then for packaging and dispensing the suspension i got these:

Oval Plastic Bottles - 4oz, Amber, CR caps - 12 pcs by AmexDrug

https://www.amazon.com/gp/product/B01GILGKYE/ref=ppx_yo_dt_b_asin_title_o05_s01?ie=UTF8&psc=1

(i will use these since i have them already and i have enough to make 3 batches, each batch a 53 day supply, so... over 5 months' worth of csuspension containers, but in the future i may order the 8 oz bottle since then i would just make the 53 day batch in 2 bottles instead of 4 bottles. not a big deal. the adaptor cap set i just oreder will fit multiple bottle neck sizes and is reusable.)

Sponix BioRx Oral Syringe - 10 mL - Best for dispensing liquids and oils - Individually Wrapped - 10 pcs by BioRx Laboratories

https://www.amazon.com/gp/product/B01BKV54YE/ref=ppx_yo_dt_b_asin_title_o05_s00?ie=UTF8&psc=1

BAXA ExactaMed Oral Liquid Medication Syringe 0.5cc/0.5mL 10/PK Clear Medicine Dose Dispenser With Cap Exacta-Med BAXTER Comar Latex Free by Baxa

https://www.amazon.com/gp/product/B01MTJPD2O/ref=ppx_yo_dt_b_asin_title_o05_s00?ie=UTF8&psc=1

Press in Bottle Adapter for Oral Medication Syringe (22mm - 25 Count) by GMS

https://www.amazon.com/gp/product/B00KZ017PC/ref=ppx_yo_dt_b_asin_title_o04_s00?ie=UTF8&th=1

OMG these SUCK! please DO NOT BUY! they are not even close to the correct size, they fall right into the bottles through the neck opening, totally usesless. also they have no kind of self sealing hole so they will just pour out the medicine through the hole. the 0.5 tiny baxa slip tip syringes fit (very tightly) but the other 10ml slip tip oral syringes didn't fit these adaptors' holes at all, would just let liquid medicine run out all over your hand while trying to dispense a dose, wasting part of the volume of your tediously prepared suspension! wasting time and money. ...ugh and i dunno if they will issue a refund or make me go through the whole stand in line at a UPS drop-off point and pay shipping 6 bucks, for basically an 8 dollar item for a 2 dollar refund? so just save yourself the time and trouble and money and skip these adaptors.

...so i ordered these as a replacement:

Ezy Dose Calibrated Oral Medicine Syringe │2 TSP (10 mL) with Bottle Adapter│Medicine Dispenser for Children by Ezy Dose Kids

https://www.amazon.com/gp/product/B0040HH7VO/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&th=1