Help needed please with figuring out titration from 0.5mg clonazepam

I would be so grateful if someone could kindly let me know how I would make up an accurate solution using water to micro titration daily?

 

I currently want to get off 0.5mg clonazepam. I have 0.5mg pills.

 

I’m happy to buy the recommended cylinders etc for more accuracy - I just need some help in devising a plan. How much would I need to make up each day and then take out if I was planning a 10% taper every 2 weeks?

 

I can get clonazepam solution 0.5mg equal to 5mls - would this be easier to do? I just don’t know how to do the maths to make it work for a daily microtaper.

 

Thank you so so much I’m advance.

I would be so grateful if someone could kindly let me know how I would make up an accurate solution using water to micro titration daily?

 

I currently want to get off 0.5mg clonazepam. I have 0.5mg pills.

 

I’m happy to buy the recommended cylinders etc for more accuracy - I just need some help in devising a plan. How much would I need to make up each day and then take out if I was planning a 10% taper every 2 weeks?

 

I can get clonazepam solution 0.5mg equal to 5mls - would this be easier to do? I just don’t know how to do the maths to make it work for a daily microtaper.

 

Thank you so so much I’m advance.

 

1)  K is NOT water-soluble, and you can NOT use plain water to "dissolve" your tablet.  You must start with a solvent (vodka or propylene glycol) to dissolve the K, then you can dilute with water.

 

2) Combine 5mg (10X .5mg tablets) with 10ml vodka or PG, and add 490 mls water.*  This will be approx a 10 day supply, .01mg per ml. Store in a closed glass jar at room temp.

 

3)  Make a taper plan.  Here's an example of a 10%/2 week schedule"

 

.5mg X 10% = .05mg

.05mg/14 days = .0035mg/day

 

Since your liquid is .001mg per ml, your daily schedule would be:

 

50ml          (5mg)

49.65ml    (4.965mg)

49.3ml      (4.93mg)

48.95ml    (4.895mg)

etc...

 

These are amounts you draw up and drink.  You do NOT discard anything.  Just lower your dose by .35mls  (.0035mgs) each day.

 

*  If you have access to Rx liquid, then its even easier.  Just dilute your Rx liquid to .01mg per ml, and follow the same schedule.

 

EDIT:  Corrected typo.

I would be so grateful if someone could kindly let me know how I would make up an accurate solution using water to micro titration daily?

 

I currently want to get off 0.5mg clonazepam. I have 0.5mg pills.

 

I’m happy to buy the recommended cylinders etc for more accuracy - I just need some help in devising a plan. How much would I need to make up each day and then take out if I was planning a 10% taper every 2 weeks?

 

I can get clonazepam solution 0.5mg equal to 5mls - would this be easier to do? I just don’t know how to do the maths to make it work for a daily microtaper.

 

Thank you so so much I’m advance.

 

Hi Mermaid2!

 

If I were in your shoes, I would use the pharmaceutical liquid .5mg=5ml. You can always dilute this pharma concentration with water if you ever feel the need.

 

Here is a program where you can Create Your Own Taper Plan by Jim Hawk. It may be helpful if you check out the Help function prior to using the program.

 

You can easily alter the program to suit your taper needs, check it out 

 

Here is a sample from Jim's program:

 

 

Good luck! 

 

 

Thank you so very much to you both! 

 

So if I get the 0.5mg/5ml oral solution I would literally just draw up eg:

Day 1: 4.982mls

Day 2: 4.964mls

Day 3: 4.946mls

Etc...

 

Is that right? I just want to make sure, sorry if I’m being dim!!

Oops, sorry, ignore me, I see that is exactly what builder has said - it’s clicked! Thank you both so much. Now just hoping I can get my hands on the oral solution xxx

One more question if you don’t mind...(and thank you in advance...)

 

Starting from 5mls (equal to 0.5mg) - with reducing the quantity per day oral solution of either 0.0175mls (for a 5% taper/14days)  or 0.035 (for a 10% taper/14 days), would I need need to keep an eye on the percentage as the drops get lower or is this already factored in? I.e do I just keep reducing either 0.0175 (if I’m doing a 5% taper rate) or 0.035 for a 10% taper from the previous day’s dose until I hit zero?

 

One more question if you don’t mind...(and thank you in advance...)

 

Starting from 5mls (equal to 0.5mg) - with reducing the quantity per day oral solution of either 0.0175mls (for a 5% taper/14days)  or 0.035 (for a 10% taper/14 days), would I need need to keep an eye on the percentage as the drops get lower or is this already factored in? I.e do I just keep reducing either 0.0175 (if I’m doing a 5% taper rate) or 0.035 for a 10% taper from the previous day’s dose until I hit zero?

 

 

 

Another big advantage of a daily microtaper is because your reduction is very gradual, the emergence of sxs, if any, will also be gradual; you will NOT get slammed with sxs as you do with a C&H taper.

 

If you feel an upswing in sxs, or if significant sxs do begin to emerge, you can hold and or change your taper rate then.  I would suggest staying at a fixed cut rate until you feel the need to slow down.

That’s really helpful, thank you. I’ll aim to start at 10%/14 days and see what happens.

 

Just to reiterate - so I don’t need to worry about readjusting the maths at any point as I drop - only readjust to take out 0.0175mls (instead of 0.035mls) from every previous days’ dose if I decide to go slower eg to 5%/14 days?

That’s really helpful, thank you. I’ll aim to start at 10%/14 days and see what happens.

 

Just to reiterate - so I don’t need to worry about readjusting the maths at any point as I drop - only readjust to take out 0.0175mls (instead of 0.035mls) from every previous days’ dose if I decide to go slower eg to 5%/14 days?

 

During my 2yr/9mg taper, I made several adjustments to my taper rate, but only on an "as needed" basis.  I was sometimes mildly symptomatic, but never really unpleasant or non-functional.  Your body warn you when you need to consider reviewing your taper plan.

Thank you for your reply.

 

Hopefully things will go smoothly enough. My only issue is that my psychiatrist has said that she won’t prescribe  the liquid until I dry cut down to 0.375mg first as she wants to see some progress. So for the last 4 days I have used tapering strips to cut to 0.45, then tonight I start 0.4 for 5 days, then drop to 0.375mg. it’s faster than I would like and I can’t really hold until I get to 0.375mg as I don’t have any back up meds to get the dosing right.

 

Praying that this doesn’t mess anything up.

Sorry for all the questions but could I please ask for a little more advice about my situation! Appreciate it so very much...

 

I have just dropped to 0.45mg clonazepam for the last 5 days via tapering strips. I can’t see my psychiatrist until the 10th October and only then has she said she will prescribe the liquid oral solution for me to daily microtaper, so that will take another few days to get.

 

I have ten 0.5mg pills left.

 

Should I:

 

A) reinstate to 0.5mg and wait until I can get the oral solution

B) try and make an oral solution myself and continue microtapering until I can get the pharma solution (I’m a little nervous about doing this as I don’t want to get it wrong)

C) continue as my psychiatrist wants and cut to 0.4375mg for 6 days (I have had to cut the pills by eye so they aren’t entirely accurate) and then cut to 0.4mg for 5 days and then 0.375mg and hold at 0.375mg until necessary by which time I should have the pharmaceutical oral solution.

 

Would really appreciate your help. So very many thanks.

 

 

 

Should I:

 

A) reinstate to 0.5mg and wait until I can get the oral solution

 

I wouldn't.  Why move the goalpost?

 

B) try and make an oral solution myself and continue microtapering until I can get the pharma solution (I’m a little nervous about doing this as I don’t want to get it wrong)

I would wait for the Rx liquid.  Rx liquid is definitely the best way to taper off of benzos

 

 

C) continue as my psychiatrist wants and cut to 0.4375mg for 6 days (I have had to cut the pills by eye so they aren’t entirely accurate) and then cut to 0.4mg for 5 days and then 0.375mg and hold at 0.375mg until necessary by which time I should have the pharmaceutical oral solution.

If you follow my suggestion on A and  B, then this really is really the default option

 

Would really appreciate your help. So very many thanks.

 

Thank you so much for your reply - I would totally hold here at 0.45mg but I don’t have enough pills (the 0.45mg were compounded for me in a specialised tapering strip which only provided 5 of them. The next drop is to 0.4375 approx which I have done myself by eye only, by pill splitting, as the tapering strip drops to 0.4mg so I was trying to lessen the blow).

 

I have no idea how to make a 0.45mg pill - unless I try and make the solution myself. So this only leaves me with the options that I’ve mentioned...

 

My husband will totally freak out if I try and make my own oral solution in our kitchen!

Builder, again thank you so much - so you think I should go with option C and hope for the best?

Builder, again thank you so much - so you think I should go with option C and hope for the best?

 

Yes, I do, but...

 

creating your own liquid is so incredibly simple that if your have concerns about staying at your current dose, maybe you want to consider it.

 

Drop 5X  .5mg tablets in 5mls vodka or PG, and add 45mls water.

 

You combine 3 ingredients.  How simple is that?  Its about as difficult as  putting cream and sugar in your hot beverage.

Thank you so much, I really appreciate it.

 

With my maths compromised brain, how much liquid of prepared solution of 50mls would I then draw up?!

Hi builder and thank you SO MUCH for your help.

 

Just checking with you if I make up the 50ml solution I’ve got this right:

 

5 x 0.5mg clonazepam pills

 

Dissolve in 5mg vodka, add 45mls water to make a 50ml solution.

 

10mls = 0.5mg

 

9mls = 0.45mg

 

8mls = 0.4mg

 

Etc...

 

Is that all correct? Thank you...

 

Hi builder and thank you SO MUCH for your help.

 

Just checking with you if I make up the 50ml solution I’ve got this right:

 

5 x 0.5mg clonazepam pills

 

Dissolve in 5mg vodka, add 45mls water to make a 50ml solution.

 

10mls = 0.5mg

 

9mls = 0.45mg

 

8mls = 0.4mg

 

Etc...

 

Is that all correct? Thank you...

 

 

I'm sorry, I made an error.  It should be 5X .5mg tablets, 5ml vodka or PG and 20mls water  Then your solution is .1mg per ml.

 

But, your numbers (.05mg per ml) will also work,  and your mg per ml conversions, as you have posted are correct.

Thank you, if you could, please could you kindly list out how this would work?

 

Eg what would the equivalent of 0.4375mg be in mls if I use the 25ml total solution? I just don’t want to get this wrong...

 

Thank you, if you could, please could you kindly list out how this would work?

 

Eg what would the equivalent of 0.4375mg be in mls if I use the 25ml total solution? I just don’t want to get this wrong...

 

 

Again, the 25ml solution would be 2.5mgs in 25mls, or .1mg per ml.

You multiply the mgs X the mls to determine the amount of liquid,  In other words, you move the decimal.

 

.4375mgs X 10 =4.375mls.  You just moved the decimal one place to the right.

 

This is why I really like  .1mg per ml solution.  There really is no math, just move the decimal.

Thank you so much for this.

 

I will try and give it a go...just praying that it works for me!

Thank you so much for this.

 

I will try and give it a go...just praying that it works for me!

 

It will! 

I’ve made the solution but there are a lot of particles that don’t seem to have dissolved - they are all over the sides of the jar and at the bottom...is this normal?! Did I not wait long enough for the vodka to dissolve the pills before adding water?!

 

Please help!

 

Please help!! Need to take my dose soon and am panicking about getting it right...

 

Really appreciate your help so much.

 

Less than 1% of your tablet is actually K, the rest is inactive ingredients...binders, fillers, colorants,etc.  Some of those inactive ingredients will be insoluble.  Don't worry about them!

 

The K will be dissolved!