Study, 2018: "Anxiolytics targeting GABAA receptors: Insights on etifoxine"

"RESULTS:  Considering the adverse effects of current treatments aimed at increasing inhibitory controls, optimisation of existing pharmacotherapies is of crucial importance. Among the alternative compounds targeting the GABAergic system, translocator protein (TSPO) ligands, such as etifoxine (EFX), which promote endogenous neurosteroidogenesis, are emerging as promising candidates for anxiety relief. In several papers comparing the efficacy of benzodiazepines and EFX, EFX showed interesting properties with limited side effects. Indeed, neurosteroids are potent GABAAR modulators with highly underrated anxiolytic properties."

 

https://www.ncbi.nlm.nih.gov/pubmed/30204559

I wonder if anyone here has tried Etifoxine & what thoughts they have?

 

Also found these articles:

 

https://onlinelibrary.wiley.com/doi/abs/10.1002/hup.757

https://en.wikipedia.org/wiki/Etifoxine

 

 

Apparently, it's associated with acute liver injury, so that's something to consider. Here's a reddit discussion of it:

 

 

There's also this article:

 

https://www.omicsonline.org/proceedings/etifoxin-unlike-benzodiazepines-potentiate-gaba-receptors-in-an--subunitdependent-manner-29221.html 

"Safety profile of etifoxine: A French pharmacovigilance survey"

 

https://onlinelibrary.wiley.com/doi/full/10.1111/fcp.12169

and this    https://www.researchgate.net/publication/270964436_Etifoxine_for_Pain_Patients_with_Anxiety

 

Not advisable for  more than 12 weeks it seems 

 

I wouldn't want to take that.

I don't know ... it appears to be better than benzos in many ways but, there appears to be a small percentage of people at least in France who suffered some liver damage. But, look what a large percentage of people who use benzodiazepines long term who suffer multi sx damage ...