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Study, Jul/18: "Severe Chronic Abuse of Zolpidem in Refractory Insomnia"


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2018 Jul 6. pii: jc-18-00052. [Epub ahead of print]

 

Severe Chronic Abuse of Zolpidem in Refractory Insomnia.

 

Chiaro G, Castelnovo A, Bianco G, Maffei P, Manconi M.

 

Abstract

 

Zolpidem is an imidazopyridine nonbenzodiazepine hypnotic drug with a high affinity to the α1 subunit of the gamma amino butyric acid A receptor It is the first pharmacological option in the short-term management of sleep-onset insomnia. Initially considered a safer drug compared to benzodiazepines because of lower liability for abuse and dependence, recently, an increasing body of reports has questioned zolpidem's proneness to misuse. In this report, we describe a case of serious zolpidem abuse requiring pharmacological washout during hospitalization because of previous withdrawal seizures in a patient with chronic sleep-onset and maintenance insomnia.

 

https://www.ncbi.nlm.nih.gov/pubmed/29991431

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