Temazepam Solubility

Does anyone know the solubility of Temazepam in PG, or if there is a better solvent for a liquid taper?  I can only seem to find it expressed as mole fraction and don't know how to convert that to mg/ml. Thanks.

I asked a pharmacologist friend.  He did the conversion.  It's approx 1.5 mg/ml.  But, if anyone knows of a better solvent, that would be great, or I'm going to have to look into doing a suspension.  This would be a taper plan for my father.

I asked a pharmacologist friend.  He did the conversion.  It's approx 1.5 mg/ml.  But, if anyone knows of a better solvent, that would be great, or I'm going to have to look into doing a suspension.  This would be a taper plan for my father.

 

PG is a great solvent.

 

And a solution using a solvent is definitely a better alternative than a suspension.

It's just the volume of pg required to dissolve 2 30mg capsules would be at least 40 ml.  What I'm thinking I might do instead is do an Ashton like switch to Klonopin.  I've got tons of that on hand.  So I'm thinking for the first 2 weeks.  1mg Clonazepam and 30 mg Temazepam.  Then switching to 2mg Clonazepam, and dry cut/liquid taper from there.  Does my math/dosages look correct?  Is that too quick of a switch?  TIA

Hi visions330

 

According to the Ashton's table of equivalencies, Clonazepam is 20 times more powerful than Diazepam and 40 times more powerful than Temazepam. So to convert  2 x 30 mg Temazepam, 1.5 mg of Clonazepam will be needed.

 

 

For information, in cases of cross-over to Diazepam some buddies gradually introduce 1 mg of Diazepam per day.

 

Hope it helps.

It's just the volume of pg required to dissolve 2 30mg capsules would be at least 40 ml.  What I'm thinking I might do instead is do an Ashton like switch to Klonopin.  I've got tons of that on hand.  So I'm thinking for the first 2 weeks.  1mg Clonazepam and 30 mg Temazepam.  Then switching to 2mg Clonazepam, and dry cut/liquid taper from there.  Does my math/dosages look correct?  Is that too quick of a switch?  TIA

 

Actually, the volume of solvent required to dissolve temazepam is lower than the volume required for V, K, etc.

 

The requirement for V and K is 2ml solvent per mg benzo.  Temazepam only requires .67ml per mg.

My god, you need a frigging degree in chemistry to understand this! Can anyone please explain titration off of Tamazapam for me? I have searched this site for simple instructions and I am losing hope because I am so scramble minded I can't understand how it's accomplished. I watched a YouTube video about water titration off of Vicodin but nothing about Tamazapam.  Could someone please dumb it down for me, please. I have been on Tamazapam for 7 months now and I want so badly to be rid of it before too much more time adds up. Anyone?

My god, you need a frigging degree in chemistry to understand this! Can anyone please explain titration off of Tamazapam for me? I have searched this site for simple instructions and I am losing hope because I am so scramble minded I can't understand how it's accomplished. I watched a YouTube video about water titration off of Vicodin but nothing about Tamazapam.  Could someone please dumb it down for me, please. I have been on Tamazapam for 7 months now and I want so badly to be rid of it before too much more time adds up. Anyone?

 

1mg temazepam + 1ml PG (or vodka) + 9ml water.

 

That's about as simple as it gets. 

 

And ignore the youtube videos! They're either wrong, overly complex, or often, both!

Thank you so much for responding. I will more than likely be bugging you alot until I get the hang of this. Apologies at the outset.

So, 15mg (my current dose) of Tamazapam + 15ml vodka + 135 ml water. Can you tell me how much is removed and when to increase the tapering? Or if you could just direct me to someone who might know? I am new to all of this. I just returned from Alternative to Meds Center and that place was an extremely expensive mistake.

So, 15mg (my current dose) of Tamazapam + 15ml vodka + 135 ml water. Can you tell me how much is removed and when to increase the tapering? Or if you could just direct me to someone who might know? I am new to all of this. I just returned from Alternative to Meds Center and that place was an extremely expensive mistake.

 

You don't remove anything, you just take less each day.

 

If you're at 15mg/day, then add 150mg + 150ml vodka + 1350 ml water.  That's about a 10-12 day supply.

 

Lets say you want to cut 10% every 15 days:

 

15mg X 10% = 1.5mg

 

1.5mg/15 days = .1mg per day  Thats the daily reduction in milligrams.

 

So your schedule will be:

 

15mg    150ml

14.9mg    149ml

14.8mg    148ml

14.7mg    147ml etc....

Ok, gotcha. So you can make a week's worth at a time? I didn't think the drug would hold potency too long being diluted in vodka. I thought you had to measure it out per dose. I only take my dose at bedtime so it's less complicated than someone who doses more often daily. My husband is overseeing this operation because I am just too scramble brained to not mess it up somehow. I appreciate your guidance.

Ok, gotcha. So you can make a week's worth at a time? I didn't think the drug would hold potency too long being diluted in vodka. I thought you had to measure it out per dose. I only take my dose at bedtime so it's less complicated than someone who doses more often daily. My husband is overseeing this operation because I am just too scramble brained to not mess it up somehow. I appreciate your guidance.

\

 

 

dissolving your benzo in a solvent will change it to a liquid, but will have no effect on its potency or efficacy.  Other than the change of state (solid to liquid) there is not any kind of degradation.

One last thing. . . I think? No need for refrigeration then?

One last thing. . . I think? No need for refrigeration then?

 

Best stored at room temp...no refrigeration needed.

Really appreciate your help. Thanks a bunch!

So, ordered and received my graduated cylinder. I measured 100ml of water into it and then poured the water into my Pyrex 2 cup glass measuring cup. The Pyrex is totally inaccurate! What measures 150ml in the cup is 130ml in the cylinder. I hate this world.

So, ordered and received my graduated cylinder. I measured 100ml of water into it and then poured the water into my Pyrex 2 cup glass measuring cup. The Pyrex is totally inaccurate! What measures 150ml in the cup is 130ml in the cylinder. I hate this world.

 

It doesn't matter.  As long as you consistently use the the measurement from the same device, you'll be fine.  (FWIW, I would trust the cylinder.)

Hi visions330

 

According to the Ashton's table of equivalencies, Clonazepam is 20 times more powerful than Diazepam and 40 times more powerful than Temazepam. So to convert  2 x 30 mg Temazepam, 1.5 mg of Clonazepam will be needed.

 

 

For information, in cases of cross-over to Diazepam some buddies gradually introduce 1 mg of Diazepam per day.

 

Hope it helps.

 

Thank you for clarifying.  I read it wrong.  Also, he was reading the wrong bottle.  He is taking 60 mg of something else.  I actually need to taper him from 15 mg Temazepam.  To be sure, 15 mg of Temazepam is equivalent to .375 mg Clonazepam? 

 

So for now, I need to get .375 mg of clonazepam per 10 ml of liquid. (if my math is correct this time.)

 

I have 1 mg Clonazepam tablets.  Could you help me with the math for fifteen 10 ml (.375mg) doses dissolved in pg/water?  Also do you think a 10% reduction in dose every 15 days would be too fast?

Thanks in advance.

Hi visions330

 

To be sure, 15 mg of Temazepam is equivalent to .375 mg Clonazepam?

Correct. 15 / 40 = 0.375

 

I need to get .375 mg of clonazepam per 10 ml of liquid.

I fear I do not understand where this 10 ml comes from.

 

I have 1 mg Clonazepam tablets.  Could you help me with the math for fifteen 10 ml (.375mg) doses dissolved in pg/water?

I propose you dissolve 2 x 1 mg tablet in 4 ml of Vodka. When completely dissolved, add 196 ml of tap water to have 200 ml of solution of 0.01 mg/ml concentration (quantity of benzo in 1 ml solution). This volume will grant you 5 doses of 0.375 mg clonazepam, each by drawing up 37.5 ml of solution.

 

Also do you think a 10% reduction in dose every 15 days would be too fast?

The general recommendations are to reduce between 5-10% every 10-14 days. So in principle your pace could be OK. The point is that this pace varies in function of individual and what works well with one may not work with another. I would rather try with the more conservative pace of 5%/14 days and gradually increase should symptoms result manageable.

 

Hope I answered your questions.

 

PS: Should you need to generate the taper plan based on a different reduction pace, go here: http://benzo.alwaysdata.net/

Thank you, thank you thank you.  This is my 75 yo father.  I'm in tears almost every day over this.  I've been on benzos legitimately  for over 25 years, and I know what happens.  As all of you I'm sure do.  He has sleep apnea and insomnia.  He uses his apap machine but wakes up with panic attacks having to rip the mask off.  His f**king sleep specialist said " I don't want you on these very long" and then gives him a 90 day supply with refills.  I didn't find out about it until he tried to stop (because this piece of shit doctor didn't explain the risks to him) and he called me up trying to fix his computer.  After him screaming at the computer 4 times, I finally asked him "Dad..... what's going on? I know you get frustrated with computers, but you just screamed at it because the start menu was smaller than it was yesterday."  He told me he hadn't slept in 3 days at all.  He said "I feel like I have a hang over, I'm shaking and everything frustrates me, I yelled at the toilet because it wasn't flushing fast enough."  This sounded way too familiar, so I asked him what meds he was on.  "I was taking memazapam(sic) but stopped 4 days ago"  I said wait, do you mean Temazepam? He went and got the bottle and said yes, Temazepam.  I explained what wad happening to him, he didn't believe me until I emailed him a list of wd symptoms.  He counted 21 symptoms on the list he had experienced over the last 3 days.  I told him go take double your dose and call me back when you are feeling better.  Sure enough, 3 hours later he called me back and was feeling good again. 

 

I love my father, and don't want him to go through what I (and the people around me) go through.  I'm balling as I write this.  Some people don't have Dad's and I am so lucky I have one who has supported .me through all my mental illness. 

 

Anyway, I wanted to get it to .375 mg/10 ml  because it would be easier for him to measure out and take 10% cuts.  He s an old man, so the the more round the number the better, and I live  2 hours away, so I can't go over every day and make his doses for him.  I can do it about twice a month, hence the 15 days.  Sorry, I'm crying and probably rambling.  I wake up too early every day because I'm taking Xanax 1mg 4x a day and get interdose withdrawal.

I'm going to go for now, but I'll be back later.  I'm sooo glad this place us here, thank you all. ❤✌

Hi visions330

 

When I get older I wish one of my two sons loves me the way you do with your dad. In his health problems, he has the chance to have a lovely supporting son like you. May all daughters/sons be good to their parents like you ❤️

 

because it would be easier for him to measure out and take 10% cuts

What if your father doesn't even have to care about the round figures, that anyway will not remain round for long following reductions, and has instead in his hands something like this:

 

 

In blue is the volume he will have to draw up each day with a syringe, swallow and check with a date when done. The only reservation I have is since the marks on a 1 ml cylinder are small, he might have some difficulty to be accurate in using it. But although there are one or more marks shifted during the operation they normally self compensate by the long half-life of Clonazepam that can soften the fluctuations of the drug in the blood stream.

 

Hope it helps.

 

All the best to your father and to you. Both of you will come out healed. It is just a matter of time.

Hi visions330

 

When I get older I wish one of my two sons loves me the way you do with your dad. In his health problems, he has the chance to have a lovely supporting son like you. May all daughters/sons be good to their parents like you ❤️

 

because it would be easier for him to measure out and take 10% cuts

What if your father doesn't even have to care about the round figures, that anyway will not remain round for long following reductions, and has instead in his hands something like this:

 

 

In blue is the volume he will have to draw up each day with a syringe, swallow and check with a date when done. The only reservation I have is since the marks on a 1 ml cylinder are small, he might have some difficulty to be accurate in using it. But although there are one or more marks shifted during the operation they normally self compensate by the long half-life of Clonazepam that can soften the fluctuations of the drug in the blood stream.

Hope it helps.

 

All the best to your father and to you. Both of you will come out healed. It is just a matter of time.

 

Ok, so this would be a daily drop in dose.  That's how I did it the first time.  I ended up back on it because I was having panic attacks every day.  I think he would be able to handle doing that.  My mind is not thinking well right now.  Would you be able to tell me how many 1mg tablets to dissolve into how much solvent?  Luckily, hes only been taking it for a litle over 4 months I think.  Thanks.  And thanks for the kind words.

Hi visions330

 

Would you be able to tell me how many 1mg tablets to dissolve into how much solvent?

I propose you dissolve 2 x 1 mg tablet in 4 ml of Vodka. When completely dissolved, add 196 ml of tap water to have 200 ml of solution of 0.01 mg/ml concentration (quantity of benzo in 1 ml solution). This volume will grant you 5 doses of 0.375 mg clonazepam, each by drawing up 37.5 ml of solution.

 

In case you need twice as much, just multiply by 2 the figures:

Ex: 4 x 1 mg tablet in 8 ml of Vodka. 392 ml of water. Total solution: 400 ml of solution of 0.01 mg/ml concentration enough for 10 doses.

Thank you.  I finally upped my own dose, I've been in damn near acute withdrawal myself for a few days.  The math doesn't look so hard now lol.  I really appreciate the help.  Much love, Bill.

 

Edit:  Can I use PG instead? I have a bunch of that on hand.  I don't have vodka/ethanol.  Thx.