Buscopan & Gaffer

Buddies,

 

Whilst traveling around Italy unknowingly in interdose WD I was treating my stomach issues with Buscopan & Gaffer.

 

Does anyone have any experience during recovery with these?

 

I'm curious if anyone knows the mechanism of action and if they act on GABA

 

Buscopan - https://en.wikipedia.org/wiki/Hyoscine_butylbromide

 

Gaffer - https://www.farmaciacanfora.com/en/otc-drugs/gastrointestinal/geffer-granulate-effervescente-24-bags/35109.html; active ingredient is https://en.wikipedia.org/wiki/Metoclopramide

 

 

I would really like to know if this is safe also.  I'm suffering from terrible IBS, so hard to breathe, but terrified to take anything, as everything upsets me

So Buscopan, or Scopolamine in the US, uses Hyoscine Butylbromide which is actually a Delrient in the same family as atropine. Which means it's using the paralytic properties of the family - acting on the Muscarinic (ACh receptor) as an antagonist.

 

Looks to not impact the GABA receptors at all, but I'm not sure of the interaction.

 

Results from Wiki & MIT lecture notes

 

Geffer is a bit more complex - Active ingredient: metoclopramide hydrochloride 5 mg, 50 mg dimethicone, potassium citrate 94.45 mg, 670 mg citric acid, tartaric acid 152 mg, 1050 mg sodium bicarbonate

 

Other ingredients: Orange flavor, sucrose.

Metroclopramide hydrochloride is a Dopamine antagonist (D2) so shouldn't hit GABA, but might interact with other medication.

 

The rest is electrolytes and antacid components.