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Study, Feb./17: Systematic review of SSRIs vs. Placebo for Major Depression


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The full title of this Danish study is "Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis".

 

"CONCLUSIONS:  SSRIs might have statistically significant effects on depressive symptoms, but all trials were at high risk of bias and the clinical significance seems questionable. SSRIs significantly increase the risk of both serious and non-serious adverse events. The potential small beneficial effects seem to be outweighed by harmful effects."

 

https://www.ncbi.nlm.nih.gov/pubmed/28178949

 

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