Study,Apr/22: Medicare prescribing trends of PPIs, antipsychotics & benzos

The full title of this American study is "Prescribing trends of proton pump inhibitors, antipsychotics and benzodiazepines of medicare part d providers".

https://pubmed.ncbi.nlm.nih.gov/35395728/

Abstract

Background: Proton pump inhibitors, benzodiazepines, and antipsychotics are considered potentially inappropriate medications in older adults according to the American Geriatric Society Beers Criteria, and deprescribing algorithms have been developed to guide use of these drug classes. The objective of this study was to describe the number of beneficiaries prescribed these medications, provider specialty and regional trends in prescribing, and the aggregate costs for these claims in Medicare Part D.

Methods: This was a retrospective cross-sectional study using publicly available Medicare Provider Utilization and Payment Data: Part D Prescriber data for years 2013-2019. Descriptive statistics and the Cochrane-Armitage test were used to summarize the trends.

Results: Overall, 30.1%, 25.6%, 4.6% of Medicare Part D beneficiaries had a proton pump inhibitor, benzodiazepine, and antipsychotic claim in 2013, respectively. These rates decreased to 27.5%, 17.5%, 4.1% in 2019 (p-value < 0.0001). However, the number of standardized 30-day claims increased from 63 million in 2013 to 84 million in 2019 for proton pump inhibitors, remained steady for benzodiazepines and slightly increased (10 million to 13 million) for antipsychotics. Total aggregate costs decreased by almost $1.5 billion for proton pump inhibitor, $100 million for benzodiazepine, and $700 million for antipsychotic from 2013 to 2019 (p-value < 0.0001). Almost 93% of gastroenterologists prescribed a proton pump inhibitor, and 60% of psychiatrists prescribed benzodiazepines and antipsychotics all seven years. The Other region had the highest percentage of providers prescribing all three classes and the highest number of standardized 30-day benzodiazepine claims.

Conclusions: The overall rate of use of proton pump inhibitors, benzodiazepines, and antipsychotics decreased from 2013-2019 among Medicare Part D beneficiaries. Despite the increase in raw number of standardized 30-day claims, the costs decreased which is likely due to generics made available. These prescribing trends may aid in identifying and targeting potential deprescribing interventions.

Keywords: Antipsychotic; Benzodiazepine; Costs; Deprescribing; Geriatric; Medication use; Proton pump inhibitor.

© 2022. The Author(s).

Conflict of interest statement

HMH is funded by Healthcare Services Corporation, a foundation of Blue Cross/Blue Shield, for a study of deprescribing. There is no relationship between the funding and this manuscript under consideration. MS is funded by Handa Oncology, for a study of drug-drug interactions. There is no relationship between the funding and this manuscript under consideration. JMT was formerly a consultant for Takeda Pharmaceutical Company, which is unrelated to this study.