Can propofol and fentanyl revv the symptoms up? I am considering an endoscopy

[[Buddie]]

I had a procedure done while in withdrawals using propofol and fentanyl. I had no problems and did just fine. I was so nervous and I think that works us up just with the worrying. I had no choice but to have it done so I accepted the process and knew I could overcome a withdrawal if it happened. Thankfully it didn’t happen and went smoothly. Good luck on your endoscopy. I’ll send positive thoughts for a successful procedure!

[[Buddie]]

Now I am over the fence if I go with midazolam or with propofol. I have it scheduled in a place that uses midazolam and fentanyl.

[[Buddie]]

I can't decide. A member here reported persistent akathisia after taking midazolam while tapering a benzo. An user on reddit reported that his mother had dementia after using propofol in this procedure.

I am very anxious and I think doing without sedation would be so stressful that would trigger some symptoms.

[[Buddie]]

I’m afraid your anxiety over the situation is worse for you than the proposed drugs they’ll use to aid in the procedure.  I’ve read many posts by members who have used Propofol and they did just fine.  Stress is a huge contributor to increased symptom severity, that’s your true villain in this case.

[[Buddie]]

I’m afraid your anxiety over the situation is worse for you than the proposed drugs they’ll use to aid in the procedure.  I’ve read many posts by members who have used Propofol and they did just fine.  Stress is a huge contributor to increased symptom severity, that’s your true villain in this case.

I guess I will go with propofol instead. I already did it. But it's a general anesthesia and it's kinda of scary. Isn't propofol much stronger than midazolam regarding gaba though?

[[Buddie]]

I had two surgeries while I was recovering and didn’t ask for any particular medication and didn’t notice an uptick in symptoms.  If you’ve decided on propofol then the only thing you need to know is that its an anesthetic and midazolam is a benzodiazepine.

[[Buddie]]

I had two surgeries while I was recovering and didn’t ask for any particular medication and didn’t notice an uptick in symptoms.  If you’ve decided on propofol then the only thing you need to know is that its an anesthetic and midazolam is a benzodiazepine.

Thank you, [...]. You've been very patient with me.

[[Buddie]]

From what I understand, Propofol affects GABA. It's a GABA-AR [...] (positive allosteric modulator), according to another member of this site who is a chemist.

Yep, according to Wikipedia, “ Propofol has been proposed as having several mechanisms of action,[71][72][73] both through potentiation of GABAA receptor activity and therefore acting as a GABAA receptor positive allosteric modulator, thereby slowing the channel-closing time.”

So what are we suppose to use for a procedure such as endoscopy?

What are the implications of these properties? Do them make it worse than midazolam?