CLONOPIN HELP! I can’t figure out taper dosage. Where is everyone?

[[Buddie]]

You’re welcome!

Re: your question about microdosing …

Are you referring to daily microtapering?  If so, there is no requirement to daily microtaper when using a compounded liquid (or any other dosage form for that matter).  You can use whatever percent reduction and reduction interval work for you and the pharmacokinetics of the benzodiazepine you are tapering.

Re: a taper plan …

Here’s an example of a Phase 1 taper plan using a total daily starting dose of 1mg of clonazepam divided into 3 doses.

Split a 0.5 tablet into quarters. (Clonazepam has a relatively long half-life plus you will be consuming the entire tablet over the course of a day so it’s ok if the pieces are not exactly the same size.)

Dose and taper as follows:

0.25mg in tablet form*+ 0.25mg in liquid form, taper liquid to zero as tolerable
0.125mg in tablet form + 0.125mg in liquid, taper liquid to zero as tolerable
0.125mg in tablet form + 0.125mg in liquid, taper liquid to zero as tolerable

*Take two of the 0.125mg pieces resulting from splitting the 0.5mg tablet into quarters

The amount of liquid ingested will depend on the concentration of the liquid.  If a 0.1mg/mL liquid is used, the starting doses would be be 2.5mL, 1.25mL, and 1.25mL.

[[Buddie]]

Wow, you’ve really gone all out here, Lib!

Thank you for providing CKing with such valuable information. You are so greatly appreciated!

[[Buddie]]

You’re welcome!

Re: your question about microdosing …

Are you referring to daily microtapering?  If so, there is no requirement to daily microtaper when using a compounded liquid (or any other dosage form for that matter).  You can use whatever percent reduction and reduction interval work for you and the pharmacokinetics of the benzodiazepine you are tapering.

Re: a taper plan …

Here’s an example of a Phase 1 taper plan using a total daily starting dose of 1mg of clonazepam divided into 3 doses.

Split a 0.5 tablet into quarters. (Clonazepam has a relatively long half-life plus you will be consuming the entire tablet over the course of a day so it’s ok if the pieces are not exactly the same size.)

Dose and taper as follows:

0.25mg in tablet form*+ 0.25mg in liquid form, taper liquid to zero as tolerable
0.125mg in tablet form + 0.125mg in liquid, taper liquid to zero as tolerable
0.125mg in tablet form + 0.125mg in liquid, taper liquid to zero as tolerable

*Take two of the 0.125mg pieces resulting from splitting the 0.5mg tablet into quarters

The amount of liquid ingested will depend on the concentration of the liquid.  If a 0.1mg/mL liquid is used, the starting doses would be be 2.5mL, 1.25mL, and 1.25mL.

Agreed! Wow! Thank you so, so much for all of the guidance - all of you! I wish I’d had this knowledge sooner, but shit happens and things change. The compounding search continues. I’m hoping my many requests won’t be met with a hang up.    This morning, back to the inaccurate cutting and weighing doses for the next week. 😩

❤️ to you all