What is titration?

We do not use 'titration' in the strict medical sense of the term. In medicine, titration describes the gradual adjustment of the dose until the desired effect is achieved. In benzo-circles, 'titration' has come to describe a procedure where water or milk is used to make a liquid from benzodiazepine tablets. To avoid confusion, since this term is already widely used within benzo-circles, we too use 'titration' to describe the making of liquid benzodiazepine. Liquidising benzodiazepine tablets enables us to make very small, very accurate cuts to our dose.

Titration is especially useful for those who find making reductions to their dose virtually impossible. This is especially true at low doses, where the size of the reductions that can be reliably obtained by pill-splitting (probably no smaller than one-quarter of a pill) can account for a large proportion of the total dose. When making liquid benzodiazepine, we recommend the use of a 100ml measuring cylinders, with 1ml graduations. This will enable you to make reductions as small as one-hundredth of a pill.

The process is pretty straightforward, and requires of you no mathamatical ability. All you need to do is provide us with the details of your benzodiazepine regimen, and we will provide a tailor-made schedule to fulfil your requirements.

Titration Preparation Procedure

We usually recommend the following preparation procedure:

  • Take one pill from your daily dose, and grind it into a fine powder with a pestle and mortar.
  • Add a little milk to the mortar and stir to collect up the powdered benzodiazepine. Pour out the benzo-milk liquid into your cylinder.
  • To ensure you have collected all of the benzodiazepine, add some more milk to the mortar and again stir. Add this liquid to the cylinder.
  • Now, carefully top up the cylinder to 100ml.
  • Stir the benzo-milk solution in the cylinder to ensure that benzodiazepine powder is evenly distributed throughout the liquid.
  • Refer to your titration table to see how much of this liquid you should take as part of your daily dose, and dispose of the remainder. Your cylinder should now contain the proportion of the single benzo tablet you require, as indicated by the titration table.
  • If your daily dose consists of more than one tablet, you should now crush the remaining tablets of your dose and add the benzo powder to the cylinder. The cylinder will now contain the whole of your daily dose.
  • The liquid in the cylinder can be split into as many doses you require over the day. If the volume is very small, top up the milk to a convenient level for you divide up over the day. Remember, the cylinder contains the whole of your daily dose at this stage, so you are only making the solution more dilute; you are not disposing of any more benzodiazepine.

The following two videos will probably make the above preparation process much clearer. Thank you, Tekksan (a member of our forum), for providing these video tutorials.

Part 1.

Part 2.

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Please regard these documents as informed opinion and not replacements for professional healthcare. We do not claim them to be complete, nor 100% correct for all people. It is important that you discuss any ideas from this website with your doctor or other appropriate healthcare practitioner.